Affected patients could be sensitized to otherwise benign alteration in vitamin consumption, RA catabolism pathways, or defects in the tooth & bone biosynthesis programs" https://t.co/7wiXkGTV8N *possibly other gene alleles add up to worse, or RA is no
Fig 7. MODEL OF HOW RA [Retinoic Acid] EXCESS IMPAIRS ENAMEL FORMATION. ... (A) Normally the entire developing tooth is shielded from RA by actions of Cyp26 RA-degrading enzymes... normal, upper https://t.co/7wiXkGTV8N Excess RA, lower; reduces expression
defects resembling human AI." same link https://t.co/7wiXkGTV8N
RT @deNutrients: animal-based study/ "RA treatments also affected bone formation, reducing mineralization. Accordingly, craniofacial ossifi…