Title |
Tissue-specific DNA methylation profiles in newborns
|
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Published in |
Clinical Epigenetics, May 2013
|
DOI | 10.1186/1868-7083-5-8 |
Pubmed ID | |
Authors |
Emilie Herzog, Jubby Galvez, Anton Roks, Lisette Stolk, Michael Verbiest, Paul Eilers, Jan Cornelissen, Eric Steegers, Régine Steegers-Theunissen |
Abstract |
Epidemiological studies demonstrate that foetal growth restriction and low birth weight affect long-term health. Derangements in tissue-specific epigenetic programming of foetal and placental tissues are a suggested underlying mechanism of which DNA methylation is best understood. DNA methylation has been mostly investigated in DNA from white blood cells. To improve baseline understanding of tissue-specific DNA methylation, we examined variation in DNA methylation profiles of the imprinted foetal growth genes IGF2 and H19 in three different tissues from the same newborn obtained at the same time. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 43% |
United States | 2 | 29% |
Panama | 1 | 14% |
Japan | 1 | 14% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Japan | 1 | 2% |
Unknown | 47 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 32% |
Researcher | 12 | 24% |
Professor | 5 | 10% |
Student > Master | 4 | 8% |
Other | 3 | 6% |
Other | 6 | 12% |
Unknown | 4 | 8% |
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---|---|---|
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Agricultural and Biological Sciences | 14 | 28% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Nursing and Health Professions | 1 | 2% |
Linguistics | 1 | 2% |
Other | 5 | 10% |
Unknown | 6 | 12% |