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Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

Overview of attention for article published in BMJ Mental Health, August 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 938)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

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121 news outlets
blogs
5 blogs
twitter
33 X users

Citations

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6 Dimensions

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34 Mendeley
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Title
Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Published in
BMJ Mental Health, August 2023
DOI 10.1136/bmjment-2023-300719
Pubmed ID
Authors

Melis Anatürk, Raihaan Patel, Klaus P. Ebmeier, Georgios Georgiopoulos, Danielle Newby, Anya Topiwala, Ann-Marie G de Lange, James H Cole, Michelle G Jansen, Archana Singh-Manoux, Mika Kivimäki, Sana Suri

Abstract

Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study. We divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then developed the risk score using competing risk regression. Our risk score, termed the UK Biobank Dementia Risk Score (UKBDRS), consisted of age, education, parental history of dementia, material deprivation, a history of diabetes, stroke, depression, hypertension, high cholesterol, household occupancy, and sex. The score had a strong discrimination accuracy in the UK Biobank test sample (area under the curve (AUC) 0.8, 95% CI 0.78 to 0.82) and in the Whitehall cohort (AUC 0.77, 95% CI 0.72 to 0.81). The UKBDRS also significantly outperformed three other widely used dementia risk scores originally developed in cohorts in Australia (the Australian National University Alzheimer's Disease Risk Index), Finland (the Cardiovascular Risk Factors, Ageing, and Dementia score), and the UK (Dementia Risk Score). Our risk score represents an easy-to-use tool to identify individuals at risk for dementia in the UK. Further research is required to determine the validity of this score in other populations.

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Other 4 12%
Student > Master 4 12%
Student > Ph. D. Student 3 9%
Student > Bachelor 3 9%
Other 4 12%
Unknown 8 24%
Readers by discipline Count As %
Medicine and Dentistry 9 26%
Neuroscience 7 21%
Psychology 3 9%
Nursing and Health Professions 2 6%
Agricultural and Biological Sciences 1 3%
Other 3 9%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 885. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2024.
All research outputs
#20,498
of 25,978,998 outputs
Outputs from BMJ Mental Health
#4
of 938 outputs
Outputs of similar age
#517
of 361,731 outputs
Outputs of similar age from BMJ Mental Health
#1
of 20 outputs
Altmetric has tracked 25,978,998 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 938 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.