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Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses

Overview of attention for article published in Nature Plants, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 990)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Citations

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101 Dimensions

Readers on

mendeley
240 Mendeley
citeulike
3 CiteULike
Title
Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses
Published in
Nature Plants, January 2017
DOI 10.1038/nplants.2016.207
Pubmed ID
Authors

Neena Mitter, Elizabeth A. Worrall, Karl E. Robinson, Peng Li, Ritesh G. Jain, Christelle Taochy, Stephen J. Fletcher, Bernard J. Carroll, G. Q. Lu, Zhi Ping Xu

Abstract

Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to transgenic RNA interference (RNAi). However, the instability of naked dsRNA sprayed on plants has been a major challenge towards its practical application. We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanosheets. Once loaded on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves even 30 days after application. We provide evidence for the degradation of LDH, dsRNA uptake in plant cells and silencing of homologous RNA on topical application. Significantly, a single spray of dsRNA loaded on LDH (BioClay) afforded virus protection for at least 20 days when challenged on sprayed and newly emerged unsprayed leaves. This innovation translates nanotechnology developed for delivery of RNAi for human therapeutics to use in crop protection as an environmentally sustainable and easy to adopt topical spray.

Twitter Demographics

The data shown below were collected from the profiles of 112 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 <1%
Chile 1 <1%
Italy 1 <1%
United Kingdom 1 <1%
Netherlands 1 <1%
Unknown 235 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 59 25%
Student > Ph. D. Student 56 23%
Unspecified 25 10%
Student > Master 24 10%
Professor > Associate Professor 19 8%
Other 57 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 129 54%
Unspecified 45 19%
Biochemistry, Genetics and Molecular Biology 36 15%
Chemistry 8 3%
Environmental Science 4 2%
Other 18 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 384. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2019.
All research outputs
#27,686
of 13,514,491 outputs
Outputs from Nature Plants
#19
of 990 outputs
Outputs of similar age
#1,768
of 374,547 outputs
Outputs of similar age from Nature Plants
#3
of 46 outputs
Altmetric has tracked 13,514,491 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 990 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,547 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.