Title |
Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD
|
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Published in |
International Journal of Chronic Obstructive Pulmonary Disease, December 2016
|
DOI | 10.2147/copd.s114209 |
Pubmed ID | |
Authors |
Peter M Calverley, Göran Eriksson, Christine R Jenkins, Antonio R Anzueto, Barry J Make, Anders Persson, Malin Fagerås, Dirkje S Postma |
Abstract |
Large clinical trials have confirmed the long-term efficacy of inhaled corticosteroid/long-acting β2-agonist combinations in patients with chronic obstructive pulmonary disease (COPD). It was hypothesized that significant treatment effects would already be present within 3 months after the initiation of treatment across a range of clinical outcomes, irrespective of COPD severity. Post hoc analysis of 3-month post-randomization outcomes, including exacerbation rates, dropouts, symptoms, reliever use, and lung function, from three studies with similar inclusion criteria of moderate-to-very-severe COPD. Patients (n=1,571) were treated with budesonide/formoterol (B/F) 320/9 μg or placebo, twice daily; in one study, tiotropium 18 μg once daily was also given. Over the first 3 months of treatment, fewer patients randomized to B/F experienced exacerbations versus the placebo group (111 and 196 patients with ≥1 exacerbation, respectively). This was true in each COPD severity group. Compared with placebo, B/F treatment led to significantly lower 3-month exacerbation rates in the moderate and severe COPD severity groups (46% and 57% reduction, respectively), with a nonsignificant reduction (29%) in very severe COPD. Fewer dropouts occurred among patients treated with B/F versus placebo, this effect being greater with increasing COPD severity. B/F was associated with improved forced expiratory volume in 1 s, morning peak expiratory flow rate, total reliever use, and total symptom score versus placebo. Treatment with B/F decreased exacerbations in patients with moderate-to-very-severe COPD within 3 months of commencing treatment. This effect was paralleled by improved lung function, less reliever medication use, and fewer symptoms, irrespective of disease severity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 20% |
Researcher | 7 | 13% |
Student > Bachelor | 7 | 13% |
Other | 4 | 7% |
Student > Postgraduate | 3 | 6% |
Other | 9 | 17% |
Unknown | 13 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 11% |
Nursing and Health Professions | 6 | 11% |
Agricultural and Biological Sciences | 3 | 6% |
Computer Science | 2 | 4% |
Other | 6 | 11% |
Unknown | 15 | 28% |