| Chapter title |
Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis
|
|---|---|
| Chapter number | 7 |
| Book title |
Signaling-Mediated Control of Cell Division
|
| Published in |
Results and problems in cell differentiation, March 2017
|
| DOI | 10.1007/978-3-319-44820-6_7 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-944819-0, 978-3-31-944820-6
|
| Authors |
Borsuk, Ewa, Jachowicz, Joanna, Kloc, Malgorzata, Tassan, Jean-Pierre, Kubiak, Jacek Z., Ewa Borsuk, Joanna Jachowicz, Malgorzata Kloc, Jean-Pierre Tassan, Jacek Z. Kubiak |
| Abstract |
Cdc6 is an important player in cell cycle regulation. It is involved in the regulation of both S-phase and M-phase. Its role during oogenesis is crucial for repression of the S-phase between the first and the second meiotic M-phases, and it also regulates, via CDK1 inhibition, the M-phase entry and exit. This is of special importance for the reactivation of the major M-phase-regulating kinase CDK1 (Cyclin-Dependent Kinase 1) in oocytes entering metaphase II of meiosis and in embryo cleavage divisions, in which precise timing allows coordination between cell cycle events and developmental program of the embryo. In this chapter, we discuss the role of Cdc6 protein in oocytes and early embryos. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 29% |
| Professor | 1 | 14% |
| Student > Bachelor | 1 | 14% |
| Student > Doctoral Student | 1 | 14% |
| Unknown | 2 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 29% |
| Biochemistry, Genetics and Molecular Biology | 1 | 14% |
| Immunology and Microbiology | 1 | 14% |
| Unknown | 3 | 43% |