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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vaccination after developing long COVID: Impact on clinical presentation, viral persistence, and immune responses
|
|---|---|
| Published in |
International Journal of Infectious Diseases, November 2023
|
| DOI | 10.1016/j.ijid.2023.09.006 |
| Pubmed ID | |
| Authors |
Maryam Nayyerabadi, Lyvia Fourcade, Swarali A. Joshi, Prabha Chandrasekaran, Arpita Chakravarti, Chantal Massé, Marie-Lorna Paul, Joanie Houle, Amina M. Boubekeur, Charlotte DuSablon, Valérie Boudreau, Danijela Bovan, Emma Darbinian, Emilia Aïsha Coleman, Sandra Vinci, Jean-Pierre Routy, Pierre-Olivier Hétu, Johanne Poudrier, Emilia Liana Falcone |
| Abstract |
Vaccination protects against severe COVID-19 manifestations. For those with post-COVID-19 conditions (PCC) or long COVID, the impact of COVID-19 vaccination on the evolution of symptoms, immune responses and viral persistence is unclear. In this prospective observational cohort study, we evaluated the number of PCC symptoms, affected organ systems and psychological well-being scores before, and after patients with PCC received COVID-19 vaccination. We simultaneously evaluated biomarkers of systemic inflammation and levels of plasma cytokines/chemokines. We measured plasma and intracellular levels of SARS-CoV-2 antigens, and immunoreactivity to SARS-CoV-2 antigens in blood. COVID-19 vaccination was associated with decreases in number of PCC symptoms (pre-vaccination: 6.56 ± 3.1 vs. post-vaccination: 3.92 ± 4.02; p<0.001) and affected organ systems (pre-vaccination: 3.19 ± 1.04 vs. post-vaccination: 1.89 ± 1.12; p<0.001), and increases in WHO-5 Well-Being Index Scores (pre-vaccination: 42.67 ± 22.76 vs. post-vaccination: 56.15 ± 22.83; p<0.001). Patients with PCC also had significantly decreased levels of several pro-inflammatory plasma cytokines/chemokines after COVID-19 vaccination including sCD40L, GRO-⍺, macrophage inflammatory protein (MIP)-1⍺, interleukin (IL)-12p40, G-colony stimulating factor (CSF), M-CSF, IL-1β and stem cell factor (SCF). PCC participants presented a certain level of immunoreactivity towards SARS-CoV-2, that was boosted with vaccination. SARS-CoV-2 S1 antigen persisted in the blood of PCC participants, mostly in non-classical monocytes, regardless of participants receiving vaccination. Our study shows higher pro-inflammatory responses associated with PCC symptoms and brings forward a possible role for vaccination in mitigating PCC symptoms by decreasing systemic inflammation. We also observed persistence of viral products independent of vaccination that could be involved in perpetuating inflammation through non-classical monocytes. |
X Demographics
The data shown below were collected from the profiles of 2,970 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 581 | 20% |
| United States | 196 | 7% |
| United Kingdom | 30 | 1% |
| Canada | 28 | <1% |
| Germany | 18 | <1% |
| Australia | 14 | <1% |
| Austria | 10 | <1% |
| Spain | 10 | <1% |
| Netherlands | 7 | <1% |
| Other | 88 | 3% |
| Unknown | 1988 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2859 | 96% |
| Practitioners (doctors, other healthcare professionals) | 50 | 2% |
| Scientists | 44 | 1% |
| Science communicators (journalists, bloggers, editors) | 16 | <1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 18% |
| Student > Bachelor | 1 | 9% |
| Other | 1 | 9% |
| Student > Master | 1 | 9% |
| Unknown | 6 | 55% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 18% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Neuroscience | 1 | 9% |
| Immunology and Microbiology | 1 | 9% |
| Unknown | 6 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1531. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#7,276
of 24,900,093 outputs
Outputs from International Journal of Infectious Diseases
#17
of 4,931 outputs
Outputs of similar age
#116
of 265,992 outputs
Outputs of similar age from International Journal of Infectious Diseases
#1
of 84 outputs
Altmetric has tracked 24,900,093 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,931 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.