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Vaccination after developing long COVID: Impact on clinical presentation, viral persistence, and immune responses

Overview of attention for article published in International Journal of Infectious Diseases, November 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 4,991)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
62 news outlets
blogs
3 blogs
twitter
2988 X users
reddit
2 Redditors
video
1 YouTube creator

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
11 Mendeley
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Title
Vaccination after developing long COVID: Impact on clinical presentation, viral persistence, and immune responses
Published in
International Journal of Infectious Diseases, November 2023
DOI 10.1016/j.ijid.2023.09.006
Pubmed ID
Authors

Maryam Nayyerabadi, Lyvia Fourcade, Swarali A. Joshi, Prabha Chandrasekaran, Arpita Chakravarti, Chantal Massé, Marie-Lorna Paul, Joanie Houle, Amina M. Boubekeur, Charlotte DuSablon, Valérie Boudreau, Danijela Bovan, Emma Darbinian, Emilia Aïsha Coleman, Sandra Vinci, Jean-Pierre Routy, Pierre-Olivier Hétu, Johanne Poudrier, Emilia Liana Falcone

Abstract

Vaccination protects against severe COVID-19 manifestations. For those with post-COVID-19 conditions (PCC) or long COVID, the impact of COVID-19 vaccination on the evolution of symptoms, immune responses and viral persistence is unclear. In this prospective observational cohort study, we evaluated the number of PCC symptoms, affected organ systems and psychological well-being scores before, and after patients with PCC received COVID-19 vaccination. We simultaneously evaluated biomarkers of systemic inflammation and levels of plasma cytokines/chemokines. We measured plasma and intracellular levels of SARS-CoV-2 antigens, and immunoreactivity to SARS-CoV-2 antigens in blood. COVID-19 vaccination was associated with decreases in number of PCC symptoms (pre-vaccination: 6.56 ± 3.1 vs. post-vaccination: 3.92 ± 4.02; p<0.001) and affected organ systems (pre-vaccination: 3.19 ± 1.04 vs. post-vaccination: 1.89 ± 1.12; p<0.001), and increases in WHO-5 Well-Being Index Scores (pre-vaccination: 42.67 ± 22.76 vs. post-vaccination: 56.15 ± 22.83; p<0.001). Patients with PCC also had significantly decreased levels of several pro-inflammatory plasma cytokines/chemokines after COVID-19 vaccination including sCD40L, GRO-⍺, macrophage inflammatory protein (MIP)-1⍺, interleukin (IL)-12p40, G-colony stimulating factor (CSF), M-CSF, IL-1β and stem cell factor (SCF). PCC participants presented a certain level of immunoreactivity towards SARS-CoV-2, that was boosted with vaccination. SARS-CoV-2 S1 antigen persisted in the blood of PCC participants, mostly in non-classical monocytes, regardless of participants receiving vaccination. Our study shows higher pro-inflammatory responses associated with PCC symptoms and brings forward a possible role for vaccination in mitigating PCC symptoms by decreasing systemic inflammation. We also observed persistence of viral products independent of vaccination that could be involved in perpetuating inflammation through non-classical monocytes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2,988 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 18%
Student > Bachelor 1 9%
Student > Ph. D. Student 1 9%
Other 1 9%
Student > Master 1 9%
Other 0 0%
Unknown 5 45%
Readers by discipline Count As %
Medicine and Dentistry 2 18%
Immunology and Microbiology 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Neuroscience 1 9%
Engineering 1 9%
Other 0 0%
Unknown 5 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1565. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2024.
All research outputs
#7,208
of 25,378,284 outputs
Outputs from International Journal of Infectious Diseases
#17
of 4,991 outputs
Outputs of similar age
#155
of 353,775 outputs
Outputs of similar age from International Journal of Infectious Diseases
#1
of 68 outputs
Altmetric has tracked 25,378,284 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,991 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.