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Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control

Overview of attention for article published in Journal of Chromatography A, June 2003
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

policy
1 policy source

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
52 Mendeley
citeulike
1 CiteULike
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Title
Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control
Published in
Journal of Chromatography A, June 2003
DOI 10.1016/s0021-9673(02)01998-2
Pubmed ID
Authors

A.J. Kueh, P.J. Marriott, P.M. Wynne, J.H. Vine

Abstract

Comprehensive two-dimensional gas chromatography (GC x GC) now occupies a niche within the GC technology regime. The technique is undeniably unique in the manner in which the experiment is conducted, the way results are presented and the interpretive opportunities offered. For the 1000th volume of this journal it is appropriate to expand upon these features, and review the progress made in GC x GC to date. Firstly, brief general comment is made on multidimensional procedures, and to review key aspects of GC x GC. The use of the targeted multidimensional GC method allows absolute retentions in the second dimension of a GC x GC experiment to be estimated, and also offers a novel way to obtain enhanced response for resolved solutes. Then, to illustrate the utility of the technique, the application of GC x GC to the screening of drugs and their metabolites in biological fluids is described using prolintane metabolites in canine urine as an example, with samples taken at four time intervals after administration. This example illustrates the first application of GC x GC in the field of forensic toxicology, an area traditionally dominated by GC-MS. Most drug compounds were found to be retained on the 0.8-m second column for a greater time than the modulation period (3 s) used for initial analysis, under the conditions described. Hence a 0.4-m D2 BPX50 (50% phenyl methyl polysilphenylene) column was then used throughout, with most compounds retained less than 4 s. For the standard drug mixture, three overlapping drugs on the first dimension column (BPX5) were subsequently baseline resolved on the BPX50 column. For prolintane administration samples, the parent drug and metabolites could be effectively resolved from background matrix peaks. Likewise a 23-drug spike standard in horse urine blank gave acceptable resolution of the drugs from matrix peaks.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Iran, Islamic Republic of 1 2%
Netherlands 1 2%
Unknown 48 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 23%
Student > Ph. D. Student 11 21%
Researcher 6 12%
Professor > Associate Professor 5 10%
Other 4 8%
Other 10 19%
Unknown 4 8%
Readers by discipline Count As %
Chemistry 23 44%
Medicine and Dentistry 6 12%
Agricultural and Biological Sciences 4 8%
Engineering 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 5 10%
Unknown 9 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2014.
All research outputs
#3,522,616
of 12,282,870 outputs
Outputs from Journal of Chromatography A
#1,665
of 9,161 outputs
Outputs of similar age
#114,699
of 335,221 outputs
Outputs of similar age from Journal of Chromatography A
#5
of 68 outputs
Altmetric has tracked 12,282,870 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,161 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.