Title |
Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions
|
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Published in |
Biology Direct, June 2013
|
DOI | 10.1186/1745-6150-8-12 |
Pubmed ID | |
Authors |
Arsen O Batagov, Igor V Kurochkin |
Abstract |
Small secreted membrane vesicles called exosomes have recently attracted a great interest after the discovery that they transfer mRNA that can be translated into protein in recipient cells. Surprisingly, we found that for the majority of exosomal mRNAs only a fraction of their corresponding probes is detectable on the expression microarrays. Exosomal mRNA fragmentation is characterized with a specific structural pattern. The closer to the 3'-end of the transcript the fragments are localized, the larger fraction among the secreted RNAs they constitute. Since the 3'-ends of transcripts contain elements conferring subcellular localization of mRNA and are rich in miRNA-binding sites, exosomal RNA may act as competing RNA to regulate stability, localization and translation activity of mRNAs in recipient cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 24% |
United States | 3 | 18% |
Brazil | 1 | 6% |
Unknown | 9 | 53% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 15 | 88% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Germany | 2 | <1% |
Sweden | 1 | <1% |
France | 1 | <1% |
Canada | 1 | <1% |
Czechia | 1 | <1% |
Unknown | 284 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 73 | 25% |
Researcher | 47 | 16% |
Student > Master | 33 | 11% |
Student > Bachelor | 26 | 9% |
Student > Doctoral Student | 21 | 7% |
Other | 34 | 12% |
Unknown | 61 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 83 | 28% |
Biochemistry, Genetics and Molecular Biology | 64 | 22% |
Medicine and Dentistry | 32 | 11% |
Engineering | 9 | 3% |
Immunology and Microbiology | 8 | 3% |
Other | 23 | 8% |
Unknown | 76 | 26% |