Title |
A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells
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Published in |
Journal of Translational Medicine, April 2013
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DOI | 10.1186/1479-5876-11-103 |
Pubmed ID | |
Authors |
Minchao Cai, Jing Wu, Chaoming Mao, Jianmin Ren, Pu Li, Xiao Li, Jiuchang Zhong, Chundi Xu, Tong Zhou |
Abstract |
Interactions between dendritic cells (DCs) and T cells play a critical role in the development of glomerulonephritis, which is a common cause of chronic kidney disease. DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), an immune-regulating molecule of the C-type lectin family, is mainly expressed on DCs and mediates DC adhesion and migration, inflammation, activation of primary T cells. DC-SIGN triggers immune responses and is involved in the immune escape of pathogens and tumours. In addition, ligation of DC-SIGN on DCs actively primes DCs to induce Tregs. Under certain conditions, DC-SIGN signalling may result in inhibition of DC maturation, by promoting regulatory T cell (Treg) function and affecting Th1/Th2 bias. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 36% |
Other | 2 | 14% |
Researcher | 2 | 14% |
Professor | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 29% |
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Medicine and Dentistry | 2 | 14% |
Chemistry | 2 | 14% |
Psychology | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |