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The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida

Overview of attention for article published in BMC Infectious Diseases, January 2017
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida
Published in
BMC Infectious Diseases, January 2017
DOI 10.1186/s12879-016-2166-y
Pubmed ID
Authors

Sebastiaan Hermanus Johannes Zegers, Jeanne Dieleman, Tjomme van der Bruggen, Jan Kimpen, Catharine de Jong-de Vos van Steenwijk

Abstract

Bacterial resistance to antibiotics is an increasingly threatening consequence of antimicrobial exposure for many decades now. In urinary tract infections (UTIs), antibiotic prophylaxis (AP) increases bacterial resistance. We studied the resistance patterns of positive urinary cultures in spina bifida children on clean intermittent catheterization, both continuing and stopping AP. In a cohort of 176 spina bifida patients, 88 continued and 88 stopped using AP. During 18 months, a fortnightly catheterized urine sample for bacterial pathogens was cultured. UTIs and significant bacteriuria (SBU) were defined as a positive culture with a single species of bacteria, respectively with and without clinical symptoms and leukocyturia. We compared the percentage of resistance to commonly used antibiotics in the isolated bacteria in both groups. In a total of 4917 cultures, 713 (14.5%) had a positive monoculture, 54.3% of which were Escherichia coli. In the group stopping AP, the resistance percentage to antibiotics in UTI / SBU bacteria was lower than in the group remaining on AP, even when excluding the administered prophylaxis. Stopping antibiotic prophylaxis for urinary tract infections is associated with reduced bacterial resistance to antibiotics in children with spina bifida. ISRCTN ISRCTN56278131 . Registered 20 December 2005.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 93 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 18%
Student > Master 9 10%
Other 8 9%
Researcher 8 9%
Student > Doctoral Student 6 6%
Other 16 17%
Unknown 29 31%
Readers by discipline Count As %
Medicine and Dentistry 35 38%
Biochemistry, Genetics and Molecular Biology 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 8%
Agricultural and Biological Sciences 3 3%
Chemistry 2 2%
Other 7 8%
Unknown 31 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2017.
All research outputs
#6,412,770
of 22,940,083 outputs
Outputs from BMC Infectious Diseases
#2,007
of 7,703 outputs
Outputs of similar age
#121,379
of 422,128 outputs
Outputs of similar age from BMC Infectious Diseases
#58
of 165 outputs
Altmetric has tracked 22,940,083 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 7,703 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,128 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.