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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
|
|---|---|
| Published in |
Nature Genetics, January 2017
|
| DOI | 10.1038/ng.3753 |
| Pubmed ID | |
| Authors |
Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale, Christine A Iacobuzio-Donahue, Andrew P Feinberg |
| Abstract |
During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death. However, the genetics of metastases largely reflects that of the primary tumor in untreated patients, and PDAC driver mutations are shared by all subclones. This raises the possibility that an epigenetic process might operate during metastasis. Here we report large-scale reprogramming of chromatin modifications during the natural evolution of distant metastasis. Changes were targeted to thousands of large chromatin domains across the genome that collectively specified malignant traits, including euchromatin and large organized chromatin histone H3 lysine 9 (H3K9)-modified (LOCK) heterochromatin. Remarkably, distant metastases co-evolved a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP), and oxPPP inhibition selectively reversed reprogrammed chromatin, malignant gene expression programs, and tumorigenesis. These findings suggest a model whereby linked metabolic-epigenetic programs are selected for enhanced tumorigenic fitness during the evolution of distant metastasis. |
X Demographics
The data shown below were collected from the profiles of 96 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 31 | 32% |
| United Kingdom | 8 | 8% |
| Canada | 4 | 4% |
| France | 3 | 3% |
| Germany | 3 | 3% |
| Australia | 2 | 2% |
| Netherlands | 2 | 2% |
| Spain | 2 | 2% |
| Greece | 1 | 1% |
| Other | 8 | 8% |
| Unknown | 32 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 55% |
| Scientists | 34 | 35% |
| Practitioners (doctors, other healthcare professionals) | 5 | 5% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 524 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| United Kingdom | 3 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 512 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 143 | 27% |
| Researcher | 92 | 18% |
| Student > Bachelor | 49 | 9% |
| Student > Master | 43 | 8% |
| Student > Doctoral Student | 31 | 6% |
| Other | 72 | 14% |
| Unknown | 94 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 198 | 38% |
| Agricultural and Biological Sciences | 102 | 19% |
| Medicine and Dentistry | 59 | 11% |
| Immunology and Microbiology | 15 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 2% |
| Other | 39 | 7% |
| Unknown | 101 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 148. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2022.
All research outputs
#284,996
of 25,775,807 outputs
Outputs from Nature Genetics
#513
of 7,621 outputs
Outputs of similar age
#6,044
of 424,629 outputs
Outputs of similar age from Nature Genetics
#15
of 72 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,621 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,629 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.