Title |
Progressive supranuclear palsy: new concepts
|
---|---|
Published in |
Arquivos de Neuro-Psiquiatria, December 2010
|
DOI | 10.1590/s0004-282x2010000600020 |
Pubmed ID | |
Authors |
Orlando Graziani Povoas Barsottini, André Carvalho Felício, Camila Catherine Henriques de Aquino, José Luiz Pedroso |
Abstract |
Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 6% |
Other | 2 | 4% |
Student > Master | 2 | 4% |
Student > Ph. D. Student | 1 | 2% |
Student > Postgraduate | 1 | 2% |
Other | 0 | 0% |
Unknown | 43 | 83% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 12% |
Neuroscience | 1 | 2% |
Psychology | 1 | 2% |
Unknown | 44 | 85% |