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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
|
|---|---|
| Published in |
Nature, January 2017
|
| DOI | 10.1038/nature20818 |
| Pubmed ID | |
| Authors |
Changchun Chen, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, Mario de Bono |
| Abstract |
Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 27% |
| United Kingdom | 4 | 8% |
| France | 2 | 4% |
| Mexico | 2 | 4% |
| Canada | 2 | 4% |
| Italy | 1 | 2% |
| Colombia | 1 | 2% |
| Greece | 1 | 2% |
| India | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 20 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 59% |
| Scientists | 15 | 31% |
| Practitioners (doctors, other healthcare professionals) | 4 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 200 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 26% |
| Researcher | 38 | 19% |
| Student > Bachelor | 18 | 9% |
| Student > Master | 16 | 8% |
| Professor | 14 | 7% |
| Other | 29 | 14% |
| Unknown | 36 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 25% |
| Neuroscience | 38 | 19% |
| Biochemistry, Genetics and Molecular Biology | 30 | 15% |
| Immunology and Microbiology | 16 | 8% |
| Medicine and Dentistry | 15 | 7% |
| Other | 15 | 7% |
| Unknown | 39 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2020.
All research outputs
#696,684
of 25,750,437 outputs
Outputs from Nature
#26,914
of 98,661 outputs
Outputs of similar age
#14,683
of 423,674 outputs
Outputs of similar age from Nature
#481
of 831 outputs
Altmetric has tracked 25,750,437 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,661 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,674 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 831 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.