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IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

Overview of attention for article published in Nature, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

2 news outlets
2 blogs
51 tweeters
1 Google+ user


35 Dimensions

Readers on

150 Mendeley
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
Published in
Nature, January 2017
DOI 10.1038/nature20818
Pubmed ID

Changchun Chen, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, Mario de Bono


Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour.

Twitter Demographics

The data shown below were collected from the profiles of 51 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 2%
United States 2 1%
Japan 1 <1%
China 1 <1%
Unknown 143 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 32%
Researcher 29 19%
Student > Bachelor 14 9%
Unspecified 13 9%
Student > Master 13 9%
Other 33 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 32%
Neuroscience 29 19%
Biochemistry, Genetics and Molecular Biology 24 16%
Unspecified 15 10%
Immunology and Microbiology 12 8%
Other 22 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2019.
All research outputs
of 13,600,802 outputs
Outputs from Nature
of 70,182 outputs
Outputs of similar age
of 346,125 outputs
Outputs of similar age from Nature
of 910 outputs
Altmetric has tracked 13,600,802 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,182 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 76.9. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 910 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.