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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats
|
|---|---|
| Published in |
International Journal of Obesity, January 2017
|
| DOI | 10.1038/ijo.2017.10 |
| Pubmed ID | |
| Authors |
G Hajiluian, G Nameni, P Shahabi, M Mesgari-Abbasi, S Sadigh-Eteghad, M A Farhangi |
| Abstract |
The purpose of this research is to investigate the effects of vitamin D administration on cognitive function, nuclear factor Kappa-B (NF-kB), brain derived neurotrophic factor (BDNF) concentration in the hippocampus and blood-brain barrier (BBB) permeability in high-fat diet (HFD) induced obese rats. Male Wistar rats were fed either a control diet or HFD for 16 weeks (n=20); then each group was randomized into two subgroups supplemented orally with 500 IU/kg vitamin D for 5 weeks. A Morris Water Maze (MWM) test was performed at the 21st week to examine cognitive function. BBB permeability was characterized by Evans blue dye in the hippocampus. BDNF and NF-κB concentrations in the hippocampus and serum vitamin D concentrations were also measured. HFD led to a significant delay in escape latency time and reduced time of MWM probe test due to increased NF-kB and decreased BDNF concentrations in the hippocampus. Vitamin D supplementation in the HFD group significantly reduced body weight, NF-κB concentrations, BBB permeability, and increased BDNF concentrations in the hippocampus. Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-kB and elevation of BDNF concentrations and modulation of the BBB permeability in rats' hippocampus.International Journal of Obesity accepted article preview online, 17 January 2017. doi:10.1038/ijo.2017.10. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 22% |
| Student > Ph. D. Student | 13 | 16% |
| Researcher | 11 | 14% |
| Other | 4 | 5% |
| Professor > Associate Professor | 3 | 4% |
| Other | 9 | 11% |
| Unknown | 22 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 16% |
| Medicine and Dentistry | 12 | 15% |
| Agricultural and Biological Sciences | 8 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 27 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2017.
All research outputs
#8,272,208
of 25,654,806 outputs
Outputs from International Journal of Obesity
#2,732
of 4,724 outputs
Outputs of similar age
#140,866
of 423,000 outputs
Outputs of similar age from International Journal of Obesity
#35
of 67 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,724 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,000 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.