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Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer

Overview of attention for article published in Current Medicinal Chemistry, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 2,102)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
107 tweeters
facebook
9 Facebook pages

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
28 Mendeley
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Title
Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer
Published in
Current Medicinal Chemistry, June 2017
DOI 10.2174/0929867324666170116122915
Pubmed ID
Authors

Matteo Vergati, Eriseld Krasniqi, Girolamo D. Monte, Silvia Riondino, Doriana Vallone, Fiorella Guadagni, Patrizia Ferroni, Mario Roselli

Abstract

Pre-clinical and clinical studies have investigated the role of a dysregulated metabolism in the sustainability of tumor initiation and progression. One of the most familiar metabolic alterations encountered in several types of cancers is the upregulation of glycolysis, which is also maintained in conditions of normal oxygen tension (aerobic glycolysis, Warburg effect) while oxidative phosphorylation is apparently reduced. As a result, cancer cells convert most incoming glucose to lactate. Although more rapid, adenosine triphosphate (ATP) production by glycolysis is less efficient in terms of ATP generated per unit of glucose consumed than oxidative phosphorylation. The consequence is that tumor cells require an abnormally higher rate of glucose compared to the normal counterpart. New evidence shows that other metabolic substrates such as glutamine may also have an important role in cancer metabolism. Ketogenic diet (KD) replaces all but non-starchy vegetable carbohydrates with low to moderate amounts of protein and high amounts of monounsaturated and polyunsaturated fats. The rationale of KD is valid both because it lowers carbohydrate uptake possibly leading to cancer cell starvation and apoptosis and, at the same time, increases the levels of ketone bodies available for energy production in normal cells but not in cancer cells which have an allegedly downregulated oxidative phosphorylation. For this reason, several authors speculate on the possibility to evaluate KD as a novel approach in the treatment of cancer. In this review we will assess the data supporting the use of such alimentary regimen and its impact on tumor development and progression.

Twitter Demographics

The data shown below were collected from the profiles of 107 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 39%
Researcher 5 18%
Student > Bachelor 4 14%
Student > Postgraduate 3 11%
Unspecified 2 7%
Other 3 11%
Readers by discipline Count As %
Medicine and Dentistry 8 29%
Nursing and Health Professions 7 25%
Biochemistry, Genetics and Molecular Biology 6 21%
Unspecified 3 11%
Agricultural and Biological Sciences 2 7%
Other 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2018.
All research outputs
#231,452
of 12,906,589 outputs
Outputs from Current Medicinal Chemistry
#5
of 2,102 outputs
Outputs of similar age
#10,730
of 341,334 outputs
Outputs of similar age from Current Medicinal Chemistry
#1
of 17 outputs
Altmetric has tracked 12,906,589 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,102 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,334 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.