Title |
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia
|
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Published in |
Cancer Discovery, November 2023
|
DOI | 10.1158/2159-8290.cd-23-0944 |
Pubmed ID | |
Authors |
Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A. Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giordanetto, Erika P. Hamilton, Katherine Harris, Michael Holliday, Tamieka L. Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R. LaRochelle, André Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M. Mader, Brenton G. Mar, Iain Martin, Thomas H. McLean, Klaus Michelsen, Yakov Pechersky, Erika Puente-Poushnejad, Kevin Raynor, Dipali Rogala, Ramin Samadani, Alison M. Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R. Williams, Hongtao Zeng, Hanmo Zhang, W. Patrick Walters, Beni B. Wolf, David E. Shaw, Donald A. Bergstrom, James Watters, James S. Fraser, Pascal D. Fortin, D. Randal Kipp |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 15% |
Sweden | 2 | 4% |
Switzerland | 2 | 4% |
Nigeria | 1 | 2% |
India | 1 | 2% |
Unknown | 34 | 72% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 55% |
Scientists | 17 | 36% |
Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 32% |
Unspecified | 4 | 10% |
Other | 2 | 5% |
Student > Ph. D. Student | 2 | 5% |
Student > Bachelor | 1 | 2% |
Other | 3 | 7% |
Unknown | 16 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 39% |
Unspecified | 4 | 10% |
Chemistry | 3 | 7% |
Agricultural and Biological Sciences | 2 | 5% |
Immunology and Microbiology | 1 | 2% |
Other | 1 | 2% |
Unknown | 14 | 34% |