Title |
Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
|
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Published in |
Journal of Neuroinflammation, September 2012
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DOI | 10.1186/1742-2094-9-213 |
Pubmed ID | |
Authors |
Roberta Brambilla, Galina Dvoriantchikova, David Barakat, Dmitry Ivanov, John R Bethea, Valery I Shestopalov |
Abstract |
Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of irreversibly damaged optic nerve axons leads to death of retinal ganglion cells, which is the cause of permanent visual impairment. Although the specific mechanisms responsible for triggering these events are unknown, it has been suggested that a key pathological factor is the activation of immune-inflammatory processes secondary to leukocyte infiltration. However, to date, there is no conclusive evidence to support such a causal role for infiltrating peripheral immune cells in the etiopathology of optic neuritis. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 20% |
Researcher | 9 | 13% |
Other | 7 | 10% |
Student > Master | 7 | 10% |
Student > Bachelor | 4 | 6% |
Other | 16 | 23% |
Unknown | 12 | 17% |
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Medicine and Dentistry | 13 | 19% |
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Immunology and Microbiology | 2 | 3% |
Other | 6 | 9% |
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