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Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

Overview of attention for article published in Journal of Neuroinflammation, September 2012
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Title
Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
Published in
Journal of Neuroinflammation, September 2012
DOI 10.1186/1742-2094-9-213
Pubmed ID
Authors

Roberta Brambilla, Galina Dvoriantchikova, David Barakat, Dmitry Ivanov, John R Bethea, Valery I Shestopalov

Abstract

Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of irreversibly damaged optic nerve axons leads to death of retinal ganglion cells, which is the cause of permanent visual impairment. Although the specific mechanisms responsible for triggering these events are unknown, it has been suggested that a key pathological factor is the activation of immune-inflammatory processes secondary to leukocyte infiltration. However, to date, there is no conclusive evidence to support such a causal role for infiltrating peripheral immune cells in the etiopathology of optic neuritis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Researcher 8 20%
Other 4 10%
Student > Master 4 10%
Student > Doctoral Student 4 10%
Other 10 24%
Unknown 1 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 37%
Medicine and Dentistry 8 20%
Biochemistry, Genetics and Molecular Biology 7 17%
Neuroscience 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 1 2%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2013.
All research outputs
#10,504,211
of 13,180,977 outputs
Outputs from Journal of Neuroinflammation
#1,111
of 1,532 outputs
Outputs of similar age
#104,485
of 151,464 outputs
Outputs of similar age from Journal of Neuroinflammation
#26
of 42 outputs
Altmetric has tracked 13,180,977 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,532 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,464 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.