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SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors.

Overview of attention for article published in Cancer Discovery, October 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 4,062)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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55 news outlets
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30 X users

Citations

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2 Dimensions

Readers on

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17 Mendeley
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Title
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors.
Published in
Cancer Discovery, October 2023
DOI 10.1158/2159-8290.cd-22-1350
Pubmed ID
Authors

Sheila López-Cobo, Jaime R Fuentealba, Paul Gueguen, Pierre-Emmanuel Bonté, Kyriaki Tsalkitzi, Irena Chacón, Salomé Glauzy, Armelle Bohineust, Ariane Biquand, Lisseth Silva, Zelia Gouveia, Christel Goudot, Franck Perez, Michael Saitakis, Sebastian Amigorena

Abstract

Failure of adoptive T cell therapies in cancer patients is linked to limited T cell expansion and persistence, even in memory-prone 41BB-(BBz)-based chimeric antigen receptor (CAR) T cells. We show here that BBz-CAR T cell stem/memory differentiation and persistence can be enhanced through epigenetic manipulation of the histone 3 lysine 9 tri-methylation (H3K9me3) pathway. Inactivation of the H3K9 tri-methyltransferase SUV39H1 enhances BBz-CAR T cell long-term persistence, protecting mice against tumor relapses and rechallenges in lung and disseminated solid tumor models up to several months after CAR T cell infusion. Single-cell transcriptomic (scRNAseq) and chromatin opening (scATACseq) analyses of tumor infiltrating CAR T cells show early reprogramming into self-renewing, stem-like populations with decreased expression of dysfunction genes in all T cell subpopulations. Therefore, epigenetic manipulation of H3K9 methylation by SUV39H1 optimizes long-term functional persistence of BBz-CAR T cells, limiting relapses and providing protection against tumor rechallenges.

X Demographics

X Demographics

The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Unspecified 3 18%
Student > Ph. D. Student 2 12%
Student > Master 2 12%
Student > Doctoral Student 1 6%
Other 1 6%
Unknown 4 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 24%
Unspecified 3 18%
Agricultural and Biological Sciences 3 18%
Immunology and Microbiology 2 12%
Medicine and Dentistry 1 6%
Other 0 0%
Unknown 4 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 434. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#65,190
of 25,374,647 outputs
Outputs from Cancer Discovery
#22
of 4,062 outputs
Outputs of similar age
#1,153
of 357,007 outputs
Outputs of similar age from Cancer Discovery
#1
of 108 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,062 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,007 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.