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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SUV39H1 Ablation Enhances Long-Term CAR-T Function in Solid Tumors
|
|---|---|
| Published in |
Cancer Discovery, November 2023
|
| DOI | 10.1158/2159-8290.cd-22-1350 |
| Pubmed ID | |
| Authors |
Sheila Lopez-Cobo, Jaime R. Fuentealba, Paul Gueguen, Pierre-Emmanuel Bonte, Kyriaki Tsalkitzi, Irena Chacon, Salome Glauzy, Armelle Bohineust, Ariane Biquand, Lisseth Silva, Zelia Gouveia, Christel Goudot, Franck Perez, Michael Saitakis, Sebastian Amigorena |
| Abstract |
Failure of adoptive T cell therapies in cancer patients is linked to limited T cell expansion and persistence, even in memory-prone 41BB-(BBz)-based chimeric antigen receptor (CAR) T cells. We show here that BBz-CAR T cell stem/memory differentiation and persistence can be enhanced through epigenetic manipulation of the histone 3 lysine 9 tri-methylation (H3K9me3) pathway. Inactivation of the H3K9 tri-methyltransferase SUV39H1 enhances BBz-CAR T cell long-term persistence, protecting mice against tumor relapses and rechallenges in lung and disseminated solid tumor models up to several months after CAR T cell infusion. Single-cell transcriptomic (scRNAseq) and chromatin opening (scATACseq) analyses of tumor infiltrating CAR T cells show early reprogramming into self-renewing, stem-like populations with decreased expression of dysfunction genes in all T cell subpopulations. Therefore, epigenetic manipulation of H3K9 methylation by SUV39H1 optimizes long-term functional persistence of BBz-CAR T cells, limiting relapses and providing protection against tumor rechallenges. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 46% |
| China | 3 | 12% |
| Canada | 1 | 4% |
| France | 1 | 4% |
| Russia | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 7 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 42% |
| Scientists | 10 | 38% |
| Science communicators (journalists, bloggers, editors) | 3 | 12% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 25% |
| Unspecified | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Student > Doctoral Student | 1 | 13% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 2 | 25% |
| Unspecified | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 432. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2023.
All research outputs
#63,696
of 24,892,887 outputs
Outputs from Cancer Discovery
#22
of 3,982 outputs
Outputs of similar age
#746
of 244,361 outputs
Outputs of similar age from Cancer Discovery
#1
of 70 outputs
Altmetric has tracked 24,892,887 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,982 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,361 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.