Title |
COMT genetic variation confers risk for psychotic and affective disorders: a case control study
|
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Published in |
Behavioral and Brain Functions, October 2005
|
DOI | 10.1186/1744-9081-1-19 |
Pubmed ID | |
Authors |
Birgit Funke, Anil K Malhotra, Christine T Finn, Alex M Plocik, Stephen L Lake, Todd Lencz, Pamela DeRosse, John M Kane, Raju Kucherlapati |
Abstract |
Variation in the COMT gene has been implicated in a number of psychiatric disorders, including psychotic, affective and anxiety disorders. The majority of these studies have focused on the functional Val108/158Met polymorphism and yielded conflicting results, with limited studies examining the relationship between other polymorphisms, or haplotypes, and psychiatric illness. We hypothesized that COMT variation may confer a general risk for psychiatric disorders and have genotyped four COMT variants (Val158Met, rs737865, rs165599, and a SNP in the P2 promoter [-278A/G; rs2097603]) in 394 Caucasian cases and 467 controls. Cases included patients with schizophrenia (n = 196), schizoaffective disorder (n = 62), bipolar disorder (n = 82), major depression (n = 30), and patients diagnosed with either psychotic disorder NOS or depressive disorder NOS (n = 24). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Canada | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 91 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 17% |
Researcher | 13 | 14% |
Student > Bachelor | 12 | 13% |
Professor | 8 | 8% |
Professor > Associate Professor | 8 | 8% |
Other | 24 | 25% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 22% |
Medicine and Dentistry | 17 | 18% |
Psychology | 15 | 16% |
Neuroscience | 8 | 8% |
Biochemistry, Genetics and Molecular Biology | 7 | 7% |
Other | 8 | 8% |
Unknown | 19 | 20% |