Title |
BigBrain: An Ultrahigh-Resolution 3D Human Brain Model
|
---|---|
Published in |
Science, June 2013
|
DOI | 10.1126/science.1235381 |
Pubmed ID | |
Authors |
Katrin Amunts, Claude Lepage, Louis Borgeat, Hartmut Mohlberg, Timo Dickscheid, Marc-Étienne Rousseau, Sebastian Bludau, Pierre-Louis Bazin, Lindsay B. Lewis, Ana-Maria Oros-Peusquens, Nadim J. Shah, Thomas Lippert, Karl Zilles, Alan C. Evans |
Abstract |
Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo. |
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United States | 29 | 13% |
United Kingdom | 12 | 5% |
Canada | 6 | 3% |
Japan | 5 | 2% |
Spain | 4 | 2% |
Denmark | 3 | 1% |
India | 3 | 1% |
Netherlands | 2 | <1% |
France | 2 | <1% |
Other | 19 | 8% |
Unknown | 142 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 154 | 68% |
Scientists | 51 | 22% |
Science communicators (journalists, bloggers, editors) | 11 | 5% |
Practitioners (doctors, other healthcare professionals) | 11 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 16 | 2% |
United Kingdom | 11 | 1% |
France | 8 | <1% |
China | 8 | <1% |
Switzerland | 5 | <1% |
Spain | 5 | <1% |
Japan | 5 | <1% |
Netherlands | 4 | <1% |
Other | 20 | 2% |
Unknown | 875 | 88% |
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Researcher | 241 | 24% |
Student > Ph. D. Student | 221 | 22% |
Student > Master | 87 | 9% |
Professor | 74 | 7% |
Student > Bachelor | 53 | 5% |
Other | 197 | 20% |
Unknown | 116 | 12% |
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Neuroscience | 176 | 18% |
Agricultural and Biological Sciences | 173 | 17% |
Medicine and Dentistry | 107 | 11% |
Psychology | 87 | 9% |
Engineering | 86 | 9% |
Other | 192 | 19% |
Unknown | 168 | 17% |