Title |
Dynamic RNA synthetic biology: new principles, practices and potential
|
---|---|
Published in |
RNA Biology, December 2023
|
DOI | 10.1080/15476286.2023.2269508 |
Pubmed ID | |
Authors |
Yueyi Li, Anibal Arce, Tyler Lucci, Rebecca A. Rasmussen, Julius B. Lucks |
Abstract |
An increased appreciation of the role of RNA dynamics in governing RNA function is ushering in a new wave of dynamic RNA synthetic biology. Here, we review recent advances in engineering dynamic RNA systems across the molecular, circuit and cellular scales for important societal-scale applications in environmental and human health, and bioproduction. For each scale, we introduce the core concepts of dynamic RNA folding and function at that scale, and then discuss technologies incorporating these concepts, covering new approaches to engineering riboswitches, ribozymes, RNA origami, RNA strand displacement circuits, biomaterials, biomolecular condensates, extracellular vesicles and synthetic cells. Considering the dynamic nature of RNA within the engineering design process promises to spark the next wave of innovation that will expand the scope and impact of RNA biotechnologies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 32% |
United Kingdom | 1 | 5% |
India | 1 | 5% |
Germany | 1 | 5% |
Unknown | 12 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 55% |
Scientists | 10 | 45% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 2 | 22% |
Researcher | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Unknown | 4 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 2 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Chemistry | 1 | 11% |
Unknown | 4 | 44% |