K562 cells have recently been shown to dynamically oscillate between two states, using CD24 as a proxy. CD24-high are more stem-like, CD24-low are more differentiated (erythroleukemic). They have different ATAC-seq profiles and functional properties. https
The second major addition to the paper is the discovery of a bromodomain-dependent cell state transition in K562 cells. Previous work (https://t.co/NdxsOmEaIe) found that individual K562 cells dynamically oscillate between CD24-high and CD24-low states. [i
RT @GenomeBiology: .@HowardYChang, @WJGreenleaf & co: Single-cell #epigenomic variability reveals functional #cancer heterogeneity https://…
Single-cell #epigenomics variability reveals functional #cancer #heterogeneity. https://t.co/oGvQGo7824