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Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

Overview of attention for article published in Gut, June 2010
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 policy source

Readers on

mendeley
176 Mendeley
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1 Connotea
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Title
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Published in
Gut, June 2010
DOI 10.1136/gut.2009.205088
Pubmed ID
Authors

V. W.-S. Wong, G. L.-H. Wong, P. C.-L. Choi, A. W.-H. Chan, M. K.-P. Li, H.-Y. Chan, A. M.-L. Chim, J. Yu, J. J.-Y. Sung, H. L.-Y. Chan

Abstract

Patients with non-alcoholic steatohepatitis (NASH) have increased mortality and liver-related complications. In contrast, simple steatosis is considered benign and non-progressive. To investigate disease progression in patients with different degrees of non-alcoholic fatty liver disease (NAFLD) activity. Prospective longitudinal hospital-based cohort study. Fifty-two patients (age 44+/-9 years) with biopsy-proven NAFLD had liver biopsies repeated at month 36. Among 13 patients with simple steatosis at baseline, 2 (15%) had a normal liver at month 36, 3 (23%) continued to have simple steatosis, 5 (39%) developed borderline NASH and 3 (23%) developed NASH. Among 22 patients with borderline NASH at baseline, 4 (18%) had simple steatosis and 13 (59%) had borderline NASH at month 36, while 5 (23%) developed NASH. Among 17 patients with NASH at baseline, 10 (59%) continued to have NASH and 6 (35%) had borderline NASH at month 36. Only 1 (6%) patient regressed to simple steatosis. Overall, 14 (27%) patients had fibrosis progression, 25 (48%) had static disease, and 13 (25%) had fibrosis regression. Reduction in body mass index and waist circumference was independently associated with non-progressive disease activity and fibrosis. The baseline serum levels and month 36 changes in adiponectin, tumour necrosis factor alpha, interleukin 6 and leptin were not associated with disease progression. Serum cytokeratin-18 fragment level reflected disease activity and its change correlated with the change in NAFLD activity score (R=0.51, p<0.001). Patients with simple steatosis may still develop NASH and fibrosis progression. Weight reduction is associated with non-progressive disease. All patients with NAFLD should undergo periodic assessment and lifestyle modification.

Mendeley readers

The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 2%
United States 2 1%
Israel 1 <1%
Switzerland 1 <1%
Unknown 168 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 15%
Student > Master 26 15%
Researcher 26 15%
Student > Postgraduate 17 10%
Student > Bachelor 17 10%
Other 41 23%
Unknown 22 13%
Readers by discipline Count As %
Medicine and Dentistry 76 43%
Biochemistry, Genetics and Molecular Biology 21 12%
Agricultural and Biological Sciences 15 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Engineering 4 2%
Other 20 11%
Unknown 35 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2016.
All research outputs
#3,572,766
of 12,361,241 outputs
Outputs from Gut
#1,874
of 4,746 outputs
Outputs of similar age
#113,551
of 333,578 outputs
Outputs of similar age from Gut
#41
of 66 outputs
Altmetric has tracked 12,361,241 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,746 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,578 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.