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Oncolytic Myxoma Virus Increases Autophagy in Multiple Myeloma

Overview of attention for article published in Turkish Journal of Hematology, March 2024
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  • Among the highest-scoring outputs from this source (#45 of 232)
  • Above-average Attention Score compared to outputs of the same age (59th percentile)

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Title
Oncolytic Myxoma Virus Increases Autophagy in Multiple Myeloma
Published in
Turkish Journal of Hematology, March 2024
DOI 10.4274/tjh.galenos.2024.2023.0403
Pubmed ID
Authors

Alpay Yeşilaltay, Dilek Muz, Berna Erdal

Abstract

Multiple myeloma (MM), which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level. In this study, we investigated the effects of Myxoma virus (MYXV), an oncolytic virus, on autophagy in myeloma cells. We analyzed protein expression of ATG-5, p62, Beclin-1, LC3B, and the apoptosis marker Bcl-2 as autophagy markers in human U-266 and mouse MOPC 315 myeloma cell lines treated with different doses of MYXV. In addition, autophagic images in myeloma cells were investigated using transmission electron microscopy (TEM). In the first 24 hours, which is the early stage of autophagy, ATG-5 and Beclin-1 expression were increased in the U-266 and MOPC-315 cell lines in the groups that received 15 multiplicity of infection (moi) MYXV. At 48 hours, a significant increase was detected in the expression of LC3B, which is a late indicator. Autophagosomes were observed in myeloma cells on TEM. MYXV shows an antimyeloma effect by increasing autophagy in myeloma cells.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 50%
Unknown 1 50%
Readers by discipline Count As %
Immunology and Microbiology 1 50%
Unknown 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#15,228,078
of 25,457,858 outputs
Outputs from Turkish Journal of Hematology
#45
of 232 outputs
Outputs of similar age
#66,793
of 170,779 outputs
Outputs of similar age from Turkish Journal of Hematology
#1
of 1 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 232 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them