Inorganic nanoporous membranes for immunoisolated cell-based drug delivery.
Therapeutic Applications of Cell Microencapsulation
Advances in experimental medicine and biology, April 2010
Mendelsohn A, Desai T, Adam Mendelsohn, Tejal Desai
Materials advances enabled by nanotecbnology have brought about promising approaches to improve the encapsulation mechanism for immunoisolated cell-based drug delivery. Cell-based drug delivery is a promising treatment for many diseases but has thus far achieved only limited clinical success. Treatment of insulin dependent diabetes mellitus (IDDM) by transplantation of pancreatic beta-cells represents the most anticipated application ofcell-based drug delivery technology. This review outlines the challenges involved with maintaining transplanted cell viability and discusses how inorganic nanoporous membranes may be useful in achieving clinical success.
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