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Immunization with Streptococcus suis bacterin plus recombinant Sao protein in sows conveys passive immunity to their piglets

Overview of attention for article published in BMC Veterinary Research, January 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

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4 tweeters

Citations

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3 Dimensions

Readers on

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30 Mendeley
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Title
Immunization with Streptococcus suis bacterin plus recombinant Sao protein in sows conveys passive immunity to their piglets
Published in
BMC Veterinary Research, January 2017
DOI 10.1186/s12917-016-0937-8
Pubmed ID
Authors

Kai-Jen Hsueh, Li-Ting Cheng, Jai-Wei Lee, Yao-Chi Chung, Wen-Bin Chung, Chun-Yen Chu

Abstract

Streptococcus suis (S. suis) causes arthritis, meningitis, septicemia, and sudden death in pigs and is also an zoonotic agent for humans. The present study demonstrated that immunization with recombinant Sao-L (surface antigen one-L, rSao-L) protein from a strain of S. suis serotype 2 in pigs was able to increase cross-serotype protection against S. suis serotype 1 and 2 challenge. Since weaning piglets are more susceptible to S. suis infections due to the stresses associated with weaning, prepartum immunization in sows may convey passive immunity to piglets and provide protection. Pregnant sows were immunized with a vaccine containing inactivated S. suis serotype 2 plus rSao as the antigens. Blood samples were collected from their piglets after birth for analysis of antigen-specific antibody titers and levels of various cytokines. Results demonstrated that the titers of S. suis and rSao-specific antibodies were significantly (p < 0.05) higher in the vaccinated piglets in comparison with that of piglets in the control group. The serum levels of interferon (IFN)-γ, interleukin (IL)-4, IL-6, and IL-12 were significantly (p < 0.05) increased in piglets born from vaccinated sows when compared to piglets from unvaccinated sows. In addition, piglets were challenged by heterologous and homologous S. suis. All piglets from unvaccinated sows developed severe symptoms of bacteremia, fever, anorexia, depression, and arthritis. On the other hand, piglets from vaccinated sows had significantly (p < 0.05) reduced clinical symptoms and lesion score (by 75 and 81%). Our results revealed that immunizing pregnant sows with the vaccine containing inactivated S. suis bacterin plus rSao as the antigens is able to enhance passive immunity against heterologous and homologous S. suis challenge in their piglets.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Researcher 5 17%
Student > Postgraduate 3 10%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 7%
Other 5 17%
Unknown 7 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 13%
Biochemistry, Genetics and Molecular Biology 4 13%
Medicine and Dentistry 3 10%
Psychology 3 10%
Immunology and Microbiology 3 10%
Other 6 20%
Unknown 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2018.
All research outputs
#7,060,008
of 13,055,200 outputs
Outputs from BMC Veterinary Research
#540
of 1,879 outputs
Outputs of similar age
#143,807
of 343,881 outputs
Outputs of similar age from BMC Veterinary Research
#11
of 50 outputs
Altmetric has tracked 13,055,200 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,879 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,881 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.