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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed
|
|---|---|
| Published in |
Scientific Reports, June 2013
|
| DOI | 10.1038/srep02084 |
| Pubmed ID | |
| Authors |
Carole Gauron, Christine Rampon, Mohamed Bouzaffour, Eliane Ipendey, Jérémie Teillon, Michel Volovitch, Sophie Vriz |
| Abstract |
A major issue in regenerative medicine is the role of injury in promoting cell plasticity. Here we explore the function of reactive oxygen species (ROS) induced through lesions in adult zebrafish. We show that ROS production, following adult fin amputation, is tightly regulated in time and space for at least 24 hours, whereas ROS production remains transient (2 hours) in mere wound healing. In regenerative tissue, ROS signaling triggers two distinct parallel pathways: one pathway is responsible for apoptosis, and the other pathway is responsible for JNK activation. Both events are involved in the compensatory proliferation of stump epidermal cells and are necessary for the progression of regeneration. Both events impact the Wnt, SDF1 and IGF pathways, while apoptosis only impacts progenitor marker expression. These results implicate oxidative stress in regeneration and provide new insights into the differences between healing and regeneration. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| United Kingdom | 1 | 14% |
| Italy | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| Portugal | 1 | <1% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 269 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 66 | 23% |
| Student > Master | 47 | 17% |
| Researcher | 37 | 13% |
| Student > Bachelor | 37 | 13% |
| Professor > Associate Professor | 18 | 6% |
| Other | 37 | 13% |
| Unknown | 39 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 33% |
| Biochemistry, Genetics and Molecular Biology | 90 | 32% |
| Engineering | 7 | 2% |
| Neuroscience | 7 | 2% |
| Medicine and Dentistry | 7 | 2% |
| Other | 30 | 11% |
| Unknown | 48 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2020.
All research outputs
#7,623,987
of 23,891,012 outputs
Outputs from Scientific Reports
#51,667
of 128,931 outputs
Outputs of similar age
#64,289
of 198,906 outputs
Outputs of similar age from Scientific Reports
#220
of 517 outputs
Altmetric has tracked 23,891,012 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 128,931 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 517 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.