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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism
|
|---|---|
| Published in |
Nature Communications, January 2017
|
| DOI | 10.1038/ncomms14237 |
| Pubmed ID | |
| Authors |
Lavinia Palamiuc, Tallie Noble, Emily Witham, Harkaranveer Ratanpal, Megan Vaughan, Supriya Srinivasan |
| Abstract |
Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major driver of body fat loss. However, mechanisms by which central serotonin action leads to fat loss remain unknown. Here, we report that the FLP-7 neuropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans. FLP-7 is secreted as a neuroendocrine peptide in proportion to fluctuations in neural serotonin circuit functions, and its release is regulated from secretory neurons via the nutrient sensor AMPK. FLP-7 acts via the NPR-22/Tachykinin2 receptor in the intestine and drives fat loss via the adipocyte triglyceride lipase ATGL-1. Importantly, this ligand-receptor pair does not alter other serotonin-dependent behaviours including food intake. For global modulators such as serotonin, the use of distinct neuroendocrine peptides for each output may be one means to achieve phenotypic selectivity. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 24% |
| Spain | 2 | 6% |
| United Kingdom | 2 | 6% |
| Netherlands | 1 | 3% |
| Romania | 1 | 3% |
| Switzerland | 1 | 3% |
| Italy | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 17 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 79% |
| Scientists | 4 | 12% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 13 | 14% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 20% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Neuroscience | 10 | 11% |
| Medicine and Dentistry | 7 | 8% |
| Psychology | 3 | 3% |
| Other | 14 | 16% |
| Unknown | 24 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 314. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2023.
All research outputs
#108,791
of 25,483,400 outputs
Outputs from Nature Communications
#1,570
of 57,306 outputs
Outputs of similar age
#2,579
of 423,259 outputs
Outputs of similar age from Nature Communications
#35
of 921 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,306 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 921 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.