Title |
The reversal of antineoplastic drug resistance in cancer cells by β‐elemene
|
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Published in |
Cancer Communications, September 2015
|
DOI | 10.1186/s40880-015-0048-0 |
Pubmed ID | |
Authors |
Guan-Nan Zhang, Charles R. Ashby, Yun-Kai Zhang, Zhe-Sheng Chen, Huiqin Guo |
Abstract |
Multidrug resistance (MDR), defined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, significantly limits the efficacy of antitumor drugs. A major mechanism that mediates MDR in cancer is the overexpression of adenosine triphosphate (ATP)-binding cassette transporters. These transporters bind to their respective substrates and catalyze their efflux from cancer cells, thereby lowering the intracellular concentrations of the substrates and thus attenuating or even abolishing their efficacy. In addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa B, and the p38 mitogen-activated protein kinase pathway. In this review, we discuss the mechanisms by which β-elemene, a compound extracted from Rhizoma zedoariae that has clinical antitumor efficacy, overcomes drug resistance in cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 30% |
Student > Bachelor | 4 | 15% |
Student > Master | 4 | 15% |
Researcher | 4 | 15% |
Professor | 1 | 4% |
Other | 3 | 11% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 30% |
Medicine and Dentistry | 6 | 22% |
Agricultural and Biological Sciences | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Business, Management and Accounting | 1 | 4% |
Other | 3 | 11% |
Unknown | 3 | 11% |