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Predicting Chronological Age via the Skin Volatile Profile

Overview of attention for article published in Journal of the American Society for Mass Spectrometry, February 2024
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  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 3,866)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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Title
Predicting Chronological Age via the Skin Volatile Profile
Published in
Journal of the American Society for Mass Spectrometry, February 2024
DOI 10.1021/jasms.3c00315
Pubmed ID
Authors

Melissa Finnegan, Shane Fitzgerald, Romain Duroux, Joan Attia, Emma Markey, David O’Connor, Aoife Morrin

Abstract

Skin volatile emissions offer a noninvasive insight into metabolic activity within the body as well as the skin microbiome and specific volatile compounds have been shown to correlate with age, albeit only in a few small studies. Building on this, here skin volatiles were collected and analyzed in a healthy participant study (n = 60) using a robust headspace-solid phase microextraction (HS-SPME) gas chromatography–mass spectrometry (GC-MS) workflow. Following processing, 18 identified compounds were deemed suitable for this study. These were classified according to gender influences and their correlations with age were investigated. Finally, 6 volatiles (of both endogenous and exogenous origin) were identified as significantly changing in abundance with participant age (p < 0.1). The potential origins of these dysregulations are discussed. Multiple linear regression (MLR) analysis was employed to model age based on these significant volatiles as independent variables, along with gender. Our analysis shows that skin volatiles show a strong predictive ability for age (explained variance of 68%), stronger than other biochemical measures collected in this study (skin surface pH, water content) which are understood to vary with chronological age. Overall, this work provides new insights into the impact of aging on the skin volatile profiles which comprises both endogenously and exogenously derived volatile compounds. It goes toward demonstrating the biological significance of skin volatiles and will help pave the way for more rigorous consideration of the healthy “baseline” skin volatile profile in volatilomics-based health diagnostics development going forward.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 40%
Unspecified 1 20%
Professor 1 20%
Lecturer > Senior Lecturer 1 20%
Readers by discipline Count As %
Unspecified 1 20%
Pharmacology, Toxicology and Pharmaceutical Science 1 20%
Energy 1 20%
Chemistry 1 20%
Engineering 1 20%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 159. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2024.
All research outputs
#260,879
of 25,637,545 outputs
Outputs from Journal of the American Society for Mass Spectrometry
#1
of 3,866 outputs
Outputs of similar age
#3,444
of 335,786 outputs
Outputs of similar age from Journal of the American Society for Mass Spectrometry
#1
of 73 outputs
Altmetric has tracked 25,637,545 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,866 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.