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In vivo silencing of alpha-synuclein using naked siRNA

Overview of attention for article published in Molecular Neurodegeneration, January 2008
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  • Good Attention Score compared to outputs of the same age (69th percentile)

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1 tweeter
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2 patents

Citations

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74 Dimensions

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121 Mendeley
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Title
In vivo silencing of alpha-synuclein using naked siRNA
Published in
Molecular Neurodegeneration, January 2008
DOI 10.1186/1750-1326-3-19
Pubmed ID
Authors

Jada Lewis, Heather Melrose, David Bumcrot, Andrew Hope, Cynthia Zehr, Sarah Lincoln, Adam Braithwaite, Zhen He, Sina Ogholikhan, Kelly Hinkle, Caroline Kent, Ivanka Toudjarska, Klaus Charisse, Ravi Braich, Rajendra K Pandey, Michael Heckman, Demetrius M Maraganore, Julia Crook, Matthew J Farrer

Abstract

Overexpression of alpha-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD. We have identified human and murine-specific siRNA molecules which reduce SNCA in vitro. As a proof of concept, we demonstrate that direct infusion of chemically modified (naked), murine-specific siRNA into the hippocampus significantly reduces SNCA levels. Reduction of SNCA in the hippocampus and cortex persists for a minimum of 1 week post-infusion with recovery nearing control levels by 3 weeks post-infusion. We have developed naked gene-specific siRNAs that silence expression of SNCA in vivo. This approach may prove beneficial toward our understanding of the endogenous functional equilibrium of SNCA, its role in disease, and eventually as a therapeutic strategy for alpha-synucleinopathies resulting from SNCA overexpression.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 18%
Student > Master 19 16%
Researcher 19 16%
Student > Bachelor 14 12%
Professor > Associate Professor 7 6%
Other 19 16%
Unknown 21 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 29%
Biochemistry, Genetics and Molecular Biology 20 17%
Neuroscience 16 13%
Medicine and Dentistry 9 7%
Engineering 4 3%
Other 12 10%
Unknown 25 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2019.
All research outputs
#4,480,689
of 16,197,328 outputs
Outputs from Molecular Neurodegeneration
#384
of 659 outputs
Outputs of similar age
#109,124
of 360,478 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 5 outputs
Altmetric has tracked 16,197,328 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 659 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,478 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.