Title |
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
|
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Published in |
Acta Neuropathologica Communications, July 2013
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DOI | 10.1186/2051-5960-1-38 |
Pubmed ID | |
Authors |
Amanda N Sacino, Mieu Brooks, Nicholas H McGarvey, Alex B McKinney, Michael A Thomas, Yona Levites, Yong Ran, Todd E Golde, Benoit I Giasson |
Abstract |
α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson's disease. Aberrant aggregation of αS also is associated with cellular demise in multiple neurologic disorders collectively referred to as synucleinopathies. Recent studies demonstrate the induction of αS pathology by a single intracerebral injection of exogenous amyloidogenic αS in adult non-transgenic and transgenic mice expressing human αS. To further investigate the mechanism of pathology induction and evaluate an experimental paradigm with potential for higher throughput, we performed similar studies in neonatal mice injected with αS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Germany | 1 | <1% |
Unknown | 103 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 27 | 25% |
Student > Master | 13 | 12% |
Researcher | 12 | 11% |
Student > Bachelor | 11 | 10% |
Professor > Associate Professor | 7 | 7% |
Other | 21 | 20% |
Unknown | 15 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 26 | 25% |
Agricultural and Biological Sciences | 24 | 23% |
Biochemistry, Genetics and Molecular Biology | 14 | 13% |
Medicine and Dentistry | 11 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 7 | 7% |
Unknown | 22 | 21% |