Title |
Trimethoprim–sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series
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Published in |
Infection, February 2017
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DOI | 10.1007/s15010-016-0968-x |
Pubmed ID | |
Authors |
Rita Murri, Barbara Fiori, Teresa Spanu, Ilaria Mastrorosa, Francesca Giovannenze, Francesco Taccari, Claudia Palazzolo, Giancarlo Scoppettuolo, Giulio Ventura, Maurizio Sanguinetti, Roberto Cauda, Massimo Fantoni |
Abstract |
The objective of the study was to evaluate the efficacy and tolerability of trimethoprim-sulfamethoxazole (also known as co-trimoxazole, TMPS) to treat Klebsiella pneumoniae (Kp)-K. pneumoniae carbapenemase (KPC) infections. Clinical data of patients with a TMPS-susceptible Kp-KPC infection were collected as a case series. We report clinical outcomes and tolerability for 14 patients infected by Kp-KPC strains susceptible to TMPS, including three bloodstream infections. In ten cases (71.4%), TMPS was administered as monotherapy. In all but one case, Kp-KPC infection was cured. In the remaining patient, therapy was discontinued because of an adverse event. The use of TMPS to treat TMPS-susceptible Kp-KPC infections seems promising. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 13% |
Spain | 2 | 13% |
Mexico | 1 | 6% |
Brazil | 1 | 6% |
Canada | 1 | 6% |
Saudi Arabia | 1 | 6% |
Bangladesh | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 63% |
Practitioners (doctors, other healthcare professionals) | 4 | 25% |
Scientists | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 17% |
Student > Master | 6 | 15% |
Student > Postgraduate | 5 | 12% |
Student > Doctoral Student | 3 | 7% |
Other | 3 | 7% |
Other | 10 | 24% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 34% |
Immunology and Microbiology | 7 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 2 | 5% |
Unknown | 9 | 22% |