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Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.

Overview of attention for article published in The Journal of Immunology, February 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
9 tweeters

Citations

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3 Dimensions

Readers on

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20 Mendeley
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Title
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.
Published in
The Journal of Immunology, February 2017
DOI 10.4049/jimmunol.1601855
Pubmed ID
Authors

Jana Blazkova, Sarthak Gupta, Yudong Liu, Brice Gaudilliere, Edward A. Ganio, Christopher R. Bolen, Ron Saar-Dover, Gabriela K. Fragiadakis, Martin S. Angst, Sarfaraz Hasni, Nima Aghaeepour, David Stevenson, Nicole Baldwin, Esperanza Anguiano, Damien Chaussabel, Matthew C. Altman, Mariana J. Kaplan, Mark M. Davis, David Furman

Abstract

Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved. In this study, we identified a gene signature of immature-like neutrophils, characterized by the overexpression of genes encoding for several granule-containing proteins, which was found at higher levels (up to 3-fold) in young (20-30 y old) but not older (60 to >89 y old) males compared with females. Functional and phenotypic characterization of peripheral blood neutrophils revealed more mature and responsive neutrophils in young females, which also exhibited an elevated capacity in neutrophil extracellular trap formation at baseline and upon microbial or sterile autoimmune stimuli. The expression levels of the immature-like neutrophil signature increased linearly with pregnancy, an immune state of increased susceptibility to certain infections. Using mass cytometry, we also find increased frequencies of immature forms of neutrophils in the blood of women during late pregnancy. Thus, our findings show novel sex differences in innate immunity and identify a common neutrophil signature in males and in pregnant women.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 30%
Student > Ph. D. Student 4 20%
Other 2 10%
Student > Doctoral Student 2 10%
Librarian 2 10%
Other 4 20%
Readers by discipline Count As %
Immunology and Microbiology 6 30%
Unspecified 3 15%
Agricultural and Biological Sciences 3 15%
Medicine and Dentistry 3 15%
Biochemistry, Genetics and Molecular Biology 2 10%
Other 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2017.
All research outputs
#2,190,593
of 9,201,335 outputs
Outputs from The Journal of Immunology
#1,036
of 7,974 outputs
Outputs of similar age
#97,695
of 317,579 outputs
Outputs of similar age from The Journal of Immunology
#66
of 200 outputs
Altmetric has tracked 9,201,335 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,974 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 200 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.