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N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2017
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Title
N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
Published in
Memórias do Instituto Oswaldo Cruz, February 2017
DOI 10.1590/0074-02760160403
Pubmed ID
Authors

Juciano Gasparotto, Alice Kunzler, Mario Roberto Senger, Celeste da Silva Freitas de Souza, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese, Floriano Paes Silva, Daniel Pens Gelain

Abstract

Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed. In liver, L. amazonensis caused thiol oxidation and nitrotyrosine formation; SOD activity and SOD2 protein content were increased while SOD1 protein content decreased. The content of the cytokines IL-1β, IL-6, TNF-α, and the receptor of advanced glycation endproducts (RAGE) increased in liver. Treatment with the antioxidant N-acetyl-cysteine (20 mg/kg b.w) for five days inhibited oxidative stress parameters. L. amazonensis induces significant alterations in the redox status of liver but not in other organs. Acute antioxidant treatment alleviates oxidative stress in liver, but it had no effect on pro-inflammatory markers. These results indicate that the pathobiology of leishmaniasis is not restricted to the cutaneous manifestations and open perspectives for the development of new therapeutic approaches to the disease, especially for liver function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Bachelor 5 12%
Student > Master 5 12%
Student > Ph. D. Student 4 10%
Professor 2 5%
Other 4 10%
Unknown 14 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 17%
Immunology and Microbiology 3 7%
Medicine and Dentistry 3 7%
Biochemistry, Genetics and Molecular Biology 3 7%
Veterinary Science and Veterinary Medicine 2 5%
Other 8 20%
Unknown 15 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,185
of 1,502 outputs
Outputs of similar age
#322,774
of 424,972 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#10
of 11 outputs
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So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.