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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Changes in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis
|
|---|---|
| Published in |
Scientific Reports, February 2017
|
| DOI | 10.1038/srep41883 |
| Pubmed ID | |
| Authors |
Javier Sotillo, Ivana Ferreira, Jeremy Potriquet, Thewarach Laha, Severine Navarro, Alex Loukas, Jason Mulvenna |
| Abstract |
Different reports have highlighted the potential use of helminths and their secretions in the treatment of inflammatory bowel disease (IBD) conditions; however, no reports have investigated their effects at a proteome level. Herein, we characterise the protein expression changes that occur in lamina propria (LP) and the intestinal epithelial cells (IEC) of mice with dextran sulfate sodium (DSS)-induced colitis treated with Ancylostoma caninum excretory/secretory (ES) products using a quantitative proteomic approach. We have shown how parasite products can significantly alter the expression of proteins involved in immune responses, cell death and with an antioxidant activity. Interestingly, significant changes in the expression levels of different mucins were observed in this study. MUC13, a mucin implicated in gastrointestinal homeostasis, was upregulated in the LP of mice with DSS-induced colitis treated with ES, while MUC2, a major component of mucus, was upregulated in the IEC. In addition, A. caninum proteins have an important effect on proteins with antioxidant functions and proteins involved in intestinal homeostasis and tissue integrity and regeneration. Understanding how parasites can ameliorate IBD pathogenesis can help us design novel treatments for autoimmune diseases. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 33% |
| United Kingdom | 1 | 11% |
| Argentina | 1 | 11% |
| Colombia | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 28% |
| Student > Bachelor | 8 | 15% |
| Student > Master | 5 | 9% |
| Other | 3 | 6% |
| Student > Postgraduate | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 8 | 15% |
| Medicine and Dentistry | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Veterinary Science and Veterinary Medicine | 5 | 9% |
| Agricultural and Biological Sciences | 4 | 8% |
| Other | 9 | 17% |
| Unknown | 14 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2018.
All research outputs
#6,274,173
of 25,489,496 outputs
Outputs from Scientific Reports
#42,872
of 141,336 outputs
Outputs of similar age
#110,232
of 432,555 outputs
Outputs of similar age from Scientific Reports
#1,412
of 4,364 outputs
Altmetric has tracked 25,489,496 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 141,336 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 432,555 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 4,364 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.