Title |
Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation
|
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Published in |
Biochemistry, November 2016
|
DOI | 10.1134/s0006297916110092 |
Pubmed ID | |
Authors |
E. O. Gubernatorova, A. V. Tumanov |
Abstract |
Ulcerative colitis and Crohn's disease are the major forms of inflammatory bowel disease. Cytokines of the tumor necrosis factor (TNF) family play an important role in the regulation of intestinal inflammation. In this review, we discuss the function of key cytokines of this family - TNF and lymphotoxin (LT) - in mucosal healing, IgA production, and in control of innate lymphoid cells (ILCs), novel regulators of mucosal homeostasis in the gut. TNF plays a central role in the pathogenesis of inflammatory bowel diseases (IBD). LT regulates group 3 of ILCs and IL-22 production and protects the epithelium against damage by chemicals and mucosal bacterial pathogens. In addition, we discuss major mouse models employed to study the mechanism of intestinal inflammation, their advantages and limitations, as well as application of TNF blockers in the therapy for IBD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 23% |
Student > Ph. D. Student | 6 | 15% |
Student > Doctoral Student | 5 | 13% |
Researcher | 5 | 13% |
Student > Bachelor | 3 | 8% |
Other | 5 | 13% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 23% |
Medicine and Dentistry | 8 | 21% |
Agricultural and Biological Sciences | 5 | 13% |
Immunology and Microbiology | 5 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 4 | 10% |
Unknown | 7 | 18% |