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Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells

Overview of attention for article published in Tohoku Journal of Experimental Medicine, January 2017
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Title
Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells
Published in
Tohoku Journal of Experimental Medicine, January 2017
DOI 10.1620/tjem.241.175
Pubmed ID
Authors

Yuki Sato, Hiroki Kato, Risa Ebina-Shibuya, Ari Itoh-Nakadai, Ryuhei Okuyama, Kazuhiko Igarashi

Abstract

Bach2 is a transcription factor which represses its target genes and plays important roles in the differentiation of B and T lymphoid cells. Bach2-deficient (KO) mice develop severe pulmonary alveolar proteinosis, which is associated with increased numbers of granulocytes and T cells. Bach2 is essential for the regulation of T cells, but its role in the regulation of granulocytes is not clear. Here, we observed increased numbers of eosinophils but not neutrophils in the bone marrow, spleen, peripheral blood, and bronchoalveolar lavage fluids of Bach2 KO mice compared with those of wild-type (WT) mice. Upon co-transplantation of the bone marrow cells from CD45.2 Bach2 KO and CD45.1/CD45.2 double-positive WT mice to irradiated WT CD45.1/CD45.2 mice, the reconstituted numbers of eosinophils were similar between Bach2 KO and WT cells. These results showed that the deficiency of Bach2 in eosinophils did not directly drive the differentiation of eosinophils. To investigate the effect of Bach2 KO CD4(+) T cells upon eosinophils, we analyzed Rag2/Bach2-double deficient (dKO) mice which lack lymphocytes including CD4(+) T cells. Rag2/Bach2 dKO mice did not show any increase in the numbers of eosinophils. Importantly, Bach2 KO mice showed an increase of interleukin-5 (Il-5) in the sera compared with WT mice. These results suggest that up-regulated functions of CD4(+) T cells including secretion of Il-5 resulted in proliferation and/or migration to peripheral tissues of eosinophils in Bach2 KO mice. We propose that Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 in CD4(+) T cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 1 13%
Student > Doctoral Student 1 13%
Student > Master 1 13%
Unknown 5 63%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 13%
Medicine and Dentistry 1 13%
Unknown 6 75%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2017.
All research outputs
#6,924,618
of 9,087,585 outputs
Outputs from Tohoku Journal of Experimental Medicine
#379
of 560 outputs
Outputs of similar age
#187,826
of 255,098 outputs
Outputs of similar age from Tohoku Journal of Experimental Medicine
#1
of 1 outputs
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So far Altmetric has tracked 560 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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