Title |
The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids
|
---|---|
Published in |
Frontiers in Genetics, January 2013
|
DOI | 10.3389/fgene.2013.00142 |
Pubmed ID | |
Authors |
Douglas D. Taylor, Cicek Gercel-Taylor |
Abstract |
We have previously demonstrated that tumor cells release membranous structures into their extracellular environment, which are termed exosomes, microvesicles or extracellular vesicles depending on specific characteristics, including size, composition and biogenesis pathway. These cell-derived vesicles can exhibit an array of proteins, lipids and nucleic acids derived from the originating tumor. This review focuses of the transcriptome (RNA) of these extracellular vesicles. Based on current data, these vesicular components play essential roles as conveyers of intercellular communication and mediators of many of the pathological conditions associated with cancer development, progression and therapeutic failures. These extracellular vesicles express components responsible for angiogenesis promotion, stromal remodeling, signal pathway activation through growth factor/receptor transfer, chemoresistance, and genetic exchange. These tumor-derived extracellular vesicles not only to represent a central mediator of the tumor microenvironment, but their presence in the peripheral circulation may serve as a surrogate for tumor biopsies, enabling real-time diagnosis and disease monitoring. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 50% |
Estonia | 1 | 25% |
Switzerland | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Brazil | 2 | <1% |
Portugal | 1 | <1% |
Korea, Republic of | 1 | <1% |
Canada | 1 | <1% |
Switzerland | 1 | <1% |
Belgium | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
Unknown | 201 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 46 | 21% |
Student > Ph. D. Student | 40 | 19% |
Student > Master | 29 | 14% |
Student > Postgraduate | 19 | 9% |
Student > Bachelor | 14 | 7% |
Other | 37 | 17% |
Unknown | 29 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 70 | 33% |
Biochemistry, Genetics and Molecular Biology | 40 | 19% |
Medicine and Dentistry | 33 | 15% |
Engineering | 10 | 5% |
Neuroscience | 8 | 4% |
Other | 23 | 11% |
Unknown | 30 | 14% |