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Mendeley readers
Attention Score in Context
| Title |
Association of β2-Adrenoreceptor Variants with Bronchial Hyperresponsiveness
|
|---|---|
| Published in |
American Journal of Respiratory & Critical Care Medicine, February 2000
|
| DOI | 10.1164/ajrccm.161.2.9902072 |
| Pubmed ID | |
| Authors |
MATTHIAS ULBRECHT, MARKUS THOMAS HERGETH, MATTHIAS WJST, JOACHIM HEINRICH, HEIKE BICKEBÖLLER, HEINZ-ERICH WICHMANN, ELISABETH HELENE WEISS |
| Abstract |
Because of its involvement in the regulation of airway tone, the beta(2)-adrenoreceptor is considered a candidate for bronchial hyperresponsiveness (BHR) associated with asthma. This notion is supported by several reports that have implicated the chromosomal region 5q31-q33 harboring the gene for the beta(2)-adrenoreceptor in the genetics of asthma and related phenotypes. We performed a population-based association study focusing on BHR as a qualitative trait and omitting other asthma-related phenotypes. From a German population sample of 1,150 individuals we extracted all 152 bronchohyperreactive probands, who were compared with 295 bronchonormoreactive control subjects. All individuals were genotyped for three single nucleotide polymorphisms of the beta(2)-adrenoreceptor gene resulting in variants at the amino acid positions 16, 27, and 164. The genotyping protocol used allowed the determination of haplotypes of these polymorphisms. Whereas no individual polymorphism was associated with BHR, the Gly16/Gln27/Th164 haplotype was significantly underrepresented in the case group indicating a protective effect of this haplotype with regard to BHR. Upon reanalysis by sex a significant association persisted only for female probands. |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 7% |
| Unknown | 13 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 14% |
| Other | 1 | 7% |
| Lecturer | 1 | 7% |
| Student > Ph. D. Student | 1 | 7% |
| Researcher | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 6 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 14% |
| Mathematics | 1 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 7% |
| Social Sciences | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 8 | 57% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2008.
All research outputs
#5,446,994
of 25,374,647 outputs
Outputs from American Journal of Respiratory & Critical Care Medicine
#4,192
of 12,493 outputs
Outputs of similar age
#11,266
of 111,367 outputs
Outputs of similar age from American Journal of Respiratory & Critical Care Medicine
#15
of 74 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,493 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.