Title |
Low-Pass DNA Sequencing of 1200 Sardinians Reconstructs European Y-Chromosome Phylogeny
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Published in |
Science, August 2013
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DOI | 10.1126/science.1237947 |
Pubmed ID | |
Authors |
Paolo Francalacci, Laura Morelli, Andrea Angius, Riccardo Berutti, Frederic Reinier, Rossano Atzeni, Rosella Pilu, Fabio Busonero, Andrea Maschio, Ilenia Zara, Daria Sanna, Antonella Useli, Maria Francesca Urru, Marco Marcelli, Roberto Cusano, Manuela Oppo, Magdalena Zoledziewska, Maristella Pitzalis, Francesca Deidda, Eleonora Porcu, Fausto Poddie, Hyun Min Kang, Robert Lyons, Brendan Tarrier, Jennifer Bragg Gresham, Bingshan Li, Sergio Tofanelli, Santos Alonso, Mariano Dei, Sandra Lai, Antonella Mulas, Michael B. Whalen, Sergio Uzzau, Chris Jones, David Schlessinger, Gonçalo R. Abecasis, Serena Sanna, Carlo Sidore, Francesco Cucca |
Abstract |
Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates. |
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Science communicators (journalists, bloggers, editors) | 1 | 2% |
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Mendeley readers
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Germany | 3 | 1% |
Italy | 2 | <1% |
Switzerland | 1 | <1% |
Chile | 1 | <1% |
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Student > Master | 15 | 7% |
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Professor > Associate Professor | 13 | 6% |
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Unknown | 45 | 21% |