Report for: Microbial production of vitamin B12: a review and future perspectives

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Title	Microbial production of vitamin B12: a review and future perspectives
Published in	Microbial Cell Factories, January 2017
DOI	10.1186/s12934-017-0631-y
Pubmed ID	28137297
Authors	Huan Fang, Jie Kang, Dawei Zhang
Abstract	Vitamin B12 is an essential vitamin that is widely used in medical and food industries. Vitamin B12 biosynthesis is confined to few bacteria and archaea, and as such its production relies on microbial fermentation. Rational strain engineering is dependent on efficient genetic tools and a detailed knowledge of metabolic pathways, regulation of which can be applied to improve product yield. Recent advances in synthetic biology and metabolic engineering have been used to efficiently construct many microbial chemical factories. Many published reviews have probed the vitamin B12 biosynthetic pathway. To maximize the potential of microbes for vitamin B12 production, new strategies and tools are required. In this review, we provide a comprehensive understanding of advances in the microbial production of vitamin B12, with a particular focus on establishing a heterologous host for the vitamin B12 production, as well as on strategies and tools that have been applied to increase microbial cobalamin production. Several worthy strategies employed for other products are also included.

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Twitter Demographics

The data shown below were collected from the profiles of 58 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	7	12%
Spain	5	9%
Chile	3	5%
Australia	1	2%
Madagascar	1	2%
Comoros	1	2%
Sweden	1	2%
Ecuador	1	2%
Switzerland	1	2%
Other	5	9%
Unknown	32	55%

Demographic breakdown

Type	Count	As %
Members of the public	46	79%
Scientists	7	12%
Practitioners (doctors, other healthcare professionals)	5	9%

Mendeley readers

The data shown below were compiled from readership statistics for 814 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Colombia	1	<1%
China	1	<1%
Germany	1	<1%
Unknown	811	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	169	21%
Student > Master	118	14%
Student > Ph. D. Student	115	14%
Researcher	75	9%
Student > Doctoral Student	32	4%
Other	84	10%
Unknown	221	27%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	201	25%
Agricultural and Biological Sciences	144	18%
Chemistry	42	5%
Immunology and Microbiology	32	4%
Medicine and Dentistry	28	3%
Other	119	15%
Unknown	248	30%

Attention Score in Context

This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2023.

All research outputs

#491,039

of 23,462,326 outputs

Outputs from Microbial Cell Factories

#13

of 1,649 outputs

Outputs of similar age

#11,809

of 422,437 outputs

Outputs of similar age from Microbial Cell Factories

of 32 outputs

Altmetric has tracked 23,462,326 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 1,649 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 99% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,437 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.

We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.

Microbial production of vitamin B12: a review and future perspectives

About this Attention Score

Mentioned by

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Twitter Demographics

Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context