Title |
Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
|
---|---|
Published in |
Acta Neuropathologica Communications, July 2013
|
DOI | 10.1186/2051-5960-1-41 |
Pubmed ID | |
Authors |
Orwa Aboud, Robert E Mrak, Frederick A Boop, W Sue T Griffin |
Abstract |
Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this outcome. Frozen and paraffin-embedded tissue samples resected from superior temporal lobes of 92 patients undergoing temporal lobectomies as a treatment for medication-resistant temporal lobe epilepsy were used in this study. To determine if epilepsy-related changes reflect those in another neurological condition, analogous tissue samples harvested from 10 autopsy-verified Alzheimer brains, and from 10 neurologically and neuropathologically normal control patients were analyzed using immunofluorescence histochemistry, western immunoblot, and real-time PCR to determine genotype effects on neuronal number and size, neuronal and glial expressions of amyloid β (Aβ) precursor protein (βAPP), Aβ, apolipoprotein E (ApoE), S100B, interleukin-1α and β, and α and β secretases; and on markers of neuronal stress, including DNA/RNA damage and caspase 3 expression. |
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Mendeley readers
Geographical breakdown
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Spain | 1 | 1% |
Ethiopia | 1 | 1% |
Unknown | 78 | 96% |
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Researcher | 14 | 17% |
Student > Bachelor | 8 | 10% |
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Psychology | 4 | 5% |
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