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Attention Score in Context
| Title |
Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic Stroke
|
|---|---|
| Published in |
PLOS ONE, August 2013
|
| DOI | 10.1371/journal.pone.0071478 |
| Pubmed ID | |
| Authors |
Vivek J. Srinivasan, Emiri T. Mandeville, Anil Can, Francesco Blasi, Mihail Climov, Ali Daneshmand, Jeong Hyun Lee, Esther Yu, Harsha Radhakrishnan, Eng H. Lo, Sava Sakadžić, Katharina Eikermann-Haerter, Cenk Ayata |
| Abstract |
Progress in experimental stroke and translational medicine could be accelerated by high-resolution in vivo imaging of disease progression in the mouse cortex. Here, we introduce optical microscopic methods that monitor brain injury progression using intrinsic optical scattering properties of cortical tissue. A multi-parametric Optical Coherence Tomography (OCT) platform for longitudinal imaging of ischemic stroke in mice, through thinned-skull, reinforced cranial window surgical preparations, is described. In the acute stages, the spatiotemporal interplay between hemodynamics and cell viability, a key determinant of pathogenesis, was imaged. In acute stroke, microscopic biomarkers for eventual infarction, including capillary non-perfusion, cerebral blood flow deficiency, altered cellular scattering, and impaired autoregulation of cerebral blood flow, were quantified and correlated with histology. Additionally, longitudinal microscopy revealed remodeling and flow recovery after one week of chronic stroke. Intrinsic scattering properties serve as reporters of acute cellular and vascular injury and recovery in experimental stroke. Multi-parametric OCT represents a robust in vivo imaging platform to comprehensively investigate these properties. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Unknown | 95 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 26% |
| Student > Ph. D. Student | 20 | 20% |
| Professor > Associate Professor | 7 | 7% |
| Student > Doctoral Student | 7 | 7% |
| Student > Master | 5 | 5% |
| Other | 17 | 17% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 22 | 22% |
| Medicine and Dentistry | 17 | 17% |
| Neuroscience | 10 | 10% |
| Agricultural and Biological Sciences | 8 | 8% |
| Physics and Astronomy | 8 | 8% |
| Other | 11 | 11% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2013.
All research outputs
#18,342,133
of 22,715,151 outputs
Outputs from PLOS ONE
#154,156
of 193,929 outputs
Outputs of similar age
#147,718
of 197,278 outputs
Outputs of similar age from PLOS ONE
#3,620
of 4,810 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,929 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,278 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,810 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.