Title |
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
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Published in |
Molecular Neurobiology, February 2017
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DOI | 10.1007/s12035-017-0451-4 |
Pubmed ID | |
Authors |
Laura Urrea, Miriam Segura-Feliu, Masami Masuda-Suzukake, Arnau Hervera, Lucas Pedraz, José Manuel García Aznar, Miquel Vila, Josep Samitier, Eduard Torrents, Isidro Ferrer, Rosalina Gavín, Masato Hagesawa, José Antonio del Río |
Abstract |
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrP(C)-overexpressing mice. In addition, α-synuclein binds strongly on PrP(C)-expressing cells, suggesting a role in modulating the effect of α-synuclein fibrils. |
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Spain | 4 | 80% |
Unknown | 1 | 20% |
Demographic breakdown
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Mendeley readers
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Student > Bachelor | 11 | 13% |
Researcher | 8 | 9% |
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Immunology and Microbiology | 3 | 3% |
Other | 3 | 3% |
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