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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
|
|---|---|
| Published in |
Nature Neuroscience, August 2013
|
| DOI | 10.1038/nn.3489 |
| Pubmed ID | |
| Authors |
Victoria S Burchell, David E Nelson, Alvaro Sanchez-Martinez, Marta Delgado-Camprubi, Rachael M Ivatt, Joe H Pogson, Suzanne J Randle, Selina Wray, Patrick A Lewis, Henry Houlden, Andrey Y Abramov, John Hardy, Nicholas W Wood, Alexander J Whitworth, Heike Laman, Helene Plun-Favreau |
| Abstract |
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box domain-containing protein Fbxo7 (encoded by PARK15) also cause early-onset autosomal recessive Parkinson's disease, by an unknown mechanism. Here we show that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy. Cells with reduced Fbxo7 expression showed deficiencies in translocation of Parkin to mitochondria, ubiquitination of mitofusin 1 and mitophagy. In Drosophila, ectopic overexpression of Fbxo7 rescued loss of Parkin, supporting a functional relationship between the two proteins. Parkinson's disease-causing mutations in Fbxo7 interfered with this process, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 7 | 44% |
| United States | 1 | 6% |
| Japan | 1 | 6% |
| France | 1 | 6% |
| Unknown | 6 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 50% |
| Science communicators (journalists, bloggers, editors) | 4 | 25% |
| Scientists | 3 | 19% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| United Kingdom | 4 | 1% |
| Switzerland | 1 | <1% |
| Austria | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 325 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 20% |
| Researcher | 63 | 19% |
| Student > Bachelor | 40 | 12% |
| Student > Master | 37 | 11% |
| Student > Doctoral Student | 12 | 4% |
| Other | 47 | 14% |
| Unknown | 73 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 30% |
| Neuroscience | 53 | 16% |
| Biochemistry, Genetics and Molecular Biology | 52 | 15% |
| Medicine and Dentistry | 35 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 1% |
| Other | 8 | 2% |
| Unknown | 85 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#564,875
of 26,017,215 outputs
Outputs from Nature Neuroscience
#1,040
of 5,702 outputs
Outputs of similar age
#4,197
of 213,612 outputs
Outputs of similar age from Nature Neuroscience
#17
of 78 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.