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Turnover of BRCA1 Involves in Radiation-Induced Apoptosis

Overview of attention for article published in PLOS ONE, December 2010
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Title
Turnover of BRCA1 Involves in Radiation-Induced Apoptosis
Published in
PLOS ONE, December 2010
DOI 10.1371/journal.pone.0014484
Pubmed ID
Authors

Weijun Liu, Wenjun Zong, George Wu, Takeo Fujita, Wenqi Li, Judy Wu, Yong Wan

Abstract

Germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) increase the susceptibility to tumorigenesis. The function of BRCA1 is to regulate critical cellular processes, including cell cycle progression, genomic integrity, and apoptosis. Studies on the regulation of BRCA1 have focused intensely on transcription and phosphorylation mechanisms. Proteolytic regulation of BRCA1 in response to stress signaling remains largely unknown. The manuscript identified a novel mechanism by which BRCA1 is regulated by the ubiquitin-dependent degradation in response to ionization.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Master 6 16%
Student > Bachelor 5 14%
Student > Ph. D. Student 5 14%
Professor > Associate Professor 3 8%
Other 4 11%
Unknown 6 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 27%
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 6 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Business, Management and Accounting 1 3%
Other 3 8%
Unknown 6 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2014.
All research outputs
#18,343,746
of 22,716,996 outputs
Outputs from PLOS ONE
#154,155
of 193,928 outputs
Outputs of similar age
#159,745
of 180,028 outputs
Outputs of similar age from PLOS ONE
#975
of 1,098 outputs
Altmetric has tracked 22,716,996 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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