You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
|
|---|---|
| Published in |
Nature Genetics, January 1995
|
| DOI | 10.1038/ng0195-48 |
| Pubmed ID | |
| Authors |
Bo Liu, Nicholas C. Nicolaides, Sanford Markowitz, James K.V. Willson, Ramon E. Parsons, Jin Jen, Nickolas Papadopolous, Päivi Peltomäki, Albert de la Chapelle, Stanley R. Hamilton, Kenneth W. Kinzler, Bert Vogelstein |
| Abstract |
Microsatellite instability has been observed in both sporadic and hereditary forms of colorectal cancer. In the hereditary form, this instability is generally due to germline mutations in mismatch repair (MMR) genes. However, only one in ten patients with sporadic tumours exhibiting microsatellite instability had a detectable germline mutation. Moreover, only three of seven sporadic tumour cell lines with microsatellite instability had mutations in a MMR gene, and these mutations could occur somatically. These results demonstrate that tumours can acquire somatic mutations that presumably do not directly affect cell growth but result only in genetic instability. They also suggest that many sporadic tumours with microsatellite instability have alterations in genes other than the four now known to participate in MMR. |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 2% |
| United Kingdom | 1 | <1% |
| Portugal | 1 | <1% |
| Finland | 1 | <1% |
| Unknown | 111 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 20% |
| Researcher | 17 | 15% |
| Student > Bachelor | 14 | 12% |
| Student > Master | 13 | 11% |
| Student > Postgraduate | 8 | 7% |
| Other | 25 | 22% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 43% |
| Biochemistry, Genetics and Molecular Biology | 19 | 16% |
| Medicine and Dentistry | 18 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Mathematics | 1 | <1% |
| Other | 6 | 5% |
| Unknown | 18 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2014.
All research outputs
#4,739,464
of 22,957,478 outputs
Outputs from Nature Genetics
#4,252
of 7,217 outputs
Outputs of similar age
#6,207
of 76,594 outputs
Outputs of similar age from Nature Genetics
#16
of 43 outputs
Altmetric has tracked 22,957,478 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.3. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.