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Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

Overview of attention for article published in Nature Genetics, January 1995
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

policy
1 policy source
patent
8 patents

Citations

dimensions_citation
609 Dimensions

Readers on

mendeley
88 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
Title
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
Published in
Nature Genetics, January 1995
DOI 10.1038/ng0195-48
Pubmed ID
Authors

Bo Liu, Nicholas C. Nicolaides, Sanford Markowitz, James K.V. Willson, Ramon E. Parsons, Jin Jen, Nickolas Papadopolous, Päivi Peltomäki, Albert de la Chapelle, Stanley R. Hamilton, Kenneth W. Kinzler, Bert Vogelstein

Abstract

Microsatellite instability has been observed in both sporadic and hereditary forms of colorectal cancer. In the hereditary form, this instability is generally due to germline mutations in mismatch repair (MMR) genes. However, only one in ten patients with sporadic tumours exhibiting microsatellite instability had a detectable germline mutation. Moreover, only three of seven sporadic tumour cell lines with microsatellite instability had mutations in a MMR gene, and these mutations could occur somatically. These results demonstrate that tumours can acquire somatic mutations that presumably do not directly affect cell growth but result only in genetic instability. They also suggest that many sporadic tumours with microsatellite instability have alterations in genes other than the four now known to participate in MMR.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 2%
United Kingdom 1 1%
Portugal 1 1%
Finland 1 1%
Philippines 1 1%
Unknown 82 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Researcher 18 20%
Student > Master 11 13%
Student > Bachelor 10 11%
Other 6 7%
Other 25 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 56%
Medicine and Dentistry 14 16%
Biochemistry, Genetics and Molecular Biology 10 11%
Unspecified 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 5 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2014.
All research outputs
#2,102,180
of 12,249,583 outputs
Outputs from Nature Genetics
#3,100
of 5,997 outputs
Outputs of similar age
#67,409
of 258,314 outputs
Outputs of similar age from Nature Genetics
#78
of 84 outputs
Altmetric has tracked 12,249,583 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,997 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,314 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.