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Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

Overview of attention for article published in Neuroscience & Biobehavioral Reviews, September 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
107 Dimensions

Readers on

mendeley
187 Mendeley
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Title
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
Published in
Neuroscience & Biobehavioral Reviews, September 2013
DOI 10.1016/j.neubiorev.2013.05.008
Pubmed ID
Authors

Ludwig Trillo, Devsmita Das, Wayne Hsieh, Brian Medina, Sarah Moghadam, Bill Lin, Van Dang, Martha Millan Sanchez, Zurine De Miguel, J. Wesson Ashford, Ahmad Salehi

Abstract

Extensive neuropathological studies have established a compelling link between abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems and the pathophysiology of Alzheimer's disease (AD). The main cell populations of these systems including the locus coeruleus, the raphe nuclei, and the tuberomamillary nucleus undergo significant degeneration in AD, thereby depriving the hippocampal and cortical neurons from their critical modulatory influence. These studies have been complemented by genome wide association studies linking polymorphisms in key genes involved in the MA-ergic systems and particular behavioral abnormalities in AD. Importantly, several recent studies have shown that improvement of the MA-ergic systems can both restore cognitive function and reduce AD-related pathology in animal models of neurodegeneration. This review aims to explore the link between abnormalities in the MA-ergic systems and AD symptomatology as well as the therapeutic strategies targeting these systems. Furthermore, we will examine possible mechanisms behind basic vulnerability of MA-ergic neurons in AD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
United Kingdom 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 182 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 25%
Student > Master 33 18%
Researcher 26 14%
Student > Bachelor 19 10%
Student > Doctoral Student 13 7%
Other 35 19%
Unknown 15 8%
Readers by discipline Count As %
Medicine and Dentistry 44 24%
Neuroscience 36 19%
Agricultural and Biological Sciences 34 18%
Psychology 19 10%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Other 25 13%
Unknown 20 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#3,802,286
of 13,583,786 outputs
Outputs from Neuroscience & Biobehavioral Reviews
#1,212
of 2,480 outputs
Outputs of similar age
#41,745
of 155,950 outputs
Outputs of similar age from Neuroscience & Biobehavioral Reviews
#23
of 49 outputs
Altmetric has tracked 13,583,786 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,480 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,950 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.